BT501 Immunology B.Tech Question Paper : wbut.ac.in
Name of the University : West Bengal University of Technology
Department : Bio-Technology
Degree : B.Tech
Sem : V
Subject Code/Name : BT-501/Immunology
Website : wbut.ac.in
Document Type : Previous Year Examination Question Paper
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WBUT Immunology Question Paper
Time Allotted : 3 Hours
Full Marks : 70
The figures in the margin indicate full marks.
Candidates are required to give their answers in their own words as far as practicable.
Related / Similar Question Paper :
WBUT BT504 Genetics & Biostatistics B.Tech Question Paper
GROUP – A :
( Multiple Choice Type Questions )
1. Choose the correct alternatives for any ten of the following : 10 × 1 = 10
i) An opsonin is
a) a chemotactic factor
b) a chemokine
c) a substance that enhances phagocytosis
d) a lysosomal enzyme.
ii) A receptor that binds antibody to a cell surface is called
a) Fc receptor b) complement receptor
c) CD molecule d) selectin.
iii) The thymus is
a) a primary lymphoid organ
b) a secondary lymphoid organ
c) a reticuloendothelial organ
d) a lymphoreticular organ.
iv) Helper T cells are distinguished by having which marker ?
a) CD2 b) CD3
c) CD4 d) IL-2 receptor.
v) The foetus can be considered
a) allograft b) xenograft
c) heterograft d) isograft.
vi) The elimination of self-reactive T cells from the thymus is called
a) negative selection b) positive selection
c) clonal selection d) apoptosis.
vii) ß2-Microglobulin is an integral part of
a) IgM b) MHC Class I
c) MHC Class II d) T cell receptor.
viii) The major force linking antigen to antibody is
a) Hydrogen bonds b) Covalent bonds
c) Hydrophobic bonds d) Ionic bonds.
ix) Maximum precipitation occurs in Ag-Ab reaction in
a) equivalence zone b) before eqivalence zone
c) after equivalence zone d) both (b) and (c).
x) Bivalent fragments of ‘Ab’ are formed by the proteolytic enzyme
a) Trypsin b) Papain
c) Pepsin d) both (b) and (c).
xi) The number of epitopes in antigen is
a) one b) two
c) three d) four.
xii) Antigen and antibody are linked by co-valent bonds.
a) True b) False
c) In some coses true d) None of these.
GROUP – B :
( Short Answer Type Questions )
Answer any three questions of the following. 3 × 5 = 15
2. How can you determine the number of possible antigenic epitopes ?
3. What is serum sickness ? How is it caused ?
4. What are toxoids ? How are used in vaccination ?
5. How do corticosteroids help in managing transplantation problems ?
6. What are the factors responsible for autoimmunity ?
GROUP – C :
( Long Answer Type Questions )
Answer any three of the following. 3 × 15 = 45
7. What are sequestered antigens ? Give examples. How can they cause autoimmune disorders ? How do steroids alleviate hypersensitivity reactions ? Why is complete Freund’s adjuvant not administered in human ? 1 + 1 + 5 + 5 + 3
8. Can you use polyclonal antibody as the first antibody in ELISA or Immunofluorescence studies ? Why ? Describe with the help of a neat flowchart the procedure for indirect immunofluorescence. What are attenuated vaccines ? Give two examples of attenuated vaccine. 1 + 3 + 6 + 3 + 2
9. Can the foetus be regarded as a graft ? Why ? What is erythroblastosis fetalis ? How is it caused ? What are the present therapies for the problem ? 2 + 3 + 2 + 4 + 4
10. What is clonal selection ? What are memory cells ? How are they produced ? If you treat a sample of polyclonal antibody with (i) pepsin and (ii) papain and run a polyacrylamide gel electrophoresis on the treated samples, what bonding patterns would you expect ? 4 + 3 + 3 + 2
11. What are the advantages and disadvantages of monoclonal antibodies ? A person develops skin disorders after wearing a metal ring. How could the problem originate ? State the therapeutic and diagnostic uses of monoclonal antibodies. 2 × 2
Immunology – 2010 :
Time Allotted : 3 Hours
Full Marks : 70
The figures in the margin indicate full marks.
Candidates are required to give their answers in their own words as far as practicable.
GROUP – A :
Multiple Choice Type Questions :
1. Choose the correct alternatives for any ten of the following : 10 × 1 = 10
i) Which category of hypersensitivity best describes hemolytic disease of the newborn caused by Rh incompatibility ?
a) Atopic or anaphylactic
b) Cytotoxic
c) Immune complex
d) Delayed.
ii) C3 is cleaved to form C3a and C3b by C3 convertase. C3b is involved in all of the following except
a) altering vascular permeability
b) promoting phagocytosis
c) forming alternative pathway C3 convertase
d) forming C5 convertase.
iii) Which class of antibody if run on reducing gel gives rise highest number of bands ?
a) IgG
b) IgM
c) IgD
d) IgA.
iv) Bone marrow transplantation in immunocompromised patients presents which major problem ?
a) Potentially lethal graft-versus-host disease
b) High risk of T cell leukemia
c) Inability to use a live donor
d) Delayed hypersensitivity.
v) AIDS is caused by a human retrovirus that kills
a) B lymphocytes
b) lymphocyte stem cells
c) CD4-positive T lymphocytes
d) CD8-positive T lymphocytes.
vi) After binding to its specific antigen, a B lymphocyte may switch its
a) immunoglobulin light chain isotype
b) immunoglobulin heavy chain class
c) variable region of the immunoglobulin heavy chain
d) constant region of the immunoglobulin light chain.
vii) “Isotype switching” of immunoglobulin classes by B cells involves
a) simultaneous insertion of VH genes adjacent to each CH gene
b) successive insertion of a single VH gene adjacent to different CH genes
c) activation of homologous genes on chromosome 6
d) switching of light chain types ( kappa and lamdba ).
viii) A primary immune response in an adult human requires approximately how much time to produce detectable antibody levels in the blood ?
a) 12 hours
b) 3 days
c) 1 week
d) 3 weeks.
ix) The membranes IgM and IgD on the surface of an individual B cell
a) have identical heavy chains but different light chains
b) are identical except for their CH regions
c) are identical except for their VH regions
d) have different VH and VL regions.
x) An antibody directed against the idiotypic determinants of human IgG antibody would react with
a) the Fc part of the IgG
b) an IgM antibody produced by the same plasma cell that produced that IgG
c) all human kappa chains
d) all human gamma chains.
xi) An Rh-negative woman married to a heterozygous Rh-positive man has three children. The probability that all three of their children are Rh-positive is
a) 1 : 2
b) 1 : 4
c) 1 : 8
d) zero.
xii) The structural basis of blood group A and B antigen specificity is
a) a single terminal sugar residue
b) a single terminal amino acid
c) multiple differences in the carbohydrate portion
d) multiple differences in the protein portion.
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