BME803D Tissue Engineering B.Tech Question Paper : wbut.ac.in
Name of the University : West Bengal University of Technology
Department : Biomedical Engineering
Degree : B.Tech
Sem : VIII
Subject Code/Name : BME-803D/Tissue Engineering
Website : wbut.ac.in
Document Type : Previous Year Examination Question Paper
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2009 : https://www.pdfquestion.in/uploads/qpaper.wbut.ac.in/6685-2009BME-803D.pdf
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WBUT Tissue Engineering Question Paper
Engineering & Management Examinations, April – 2009 :
Semester – 8 :
Time : 3 Hours
Full Marks : 70
Related / Similar Question Paper : WBUT B.Tech Modeling Of Physiological System Question Paper
GROUP – A
( Multiple Choice Type Questions )
1. Choose the correct alternatives for the following : 10 8 1 = 10
i) The formation of blood vessel from the pre-existing blood vessel is known as
a) angiogenesis b) vascularization
c) osteogenesis d) phagocytosis.
ii) The Major Histocompatibility Complexes ( MHCs ) are
a) signaling molecules b) growth factors
c) cell surface markers d) cell adhesion molecules.
iii) Bone Morphogenic Protein ( BMP ) is a
a) cell surface marker b) growth factors
c) hormone d) neurotransmitter.
iv) Polyglycolic Acid ( PGA ) scaffold is
a) biotolerant b) bioactive
c) bioinert d) biodegradable.
v) In tissue engineering, harvested cells are frozen away and stored in
a) liquid hydrogen b) liquid nitrogen
c) liquid helium d) autoclave.
vi) Cell signaling compounds cytokines are a group of
a) proteins and peptides b) fats and triglycerides
c) carbohydrates d) hormones and steroids.
vii) c-AMP and c-GMP functions as
a) hormone b) receptor
c) second messenger d) ligand.
viii) The signals which affect only cells of the same cell type as the emitting cell are
a) endocrine b) autocrine
c) paracrine d) none of these.
ix) Carbon nanotubes are used for tissue engineering scaffolds as they are
a) biocompatible b) biodegradable
c) biopolymers d) none of these.
x) PLA degrades within the body to form
a) amino acid b) glycolic acid
c) lactic acid d) phosphoric acid.
GROUP – B
( Short Answer Type Questions )
Answer any three of the following. 3 8 5 = 15
2. What are CAMs ? What are the different types of CAMs associated with cell signalling ? How do CAMs help to transmit signals ? 2 + 2 + 1
3. What are the basic criteria of a scaffold used for tissue reconstruction ? Give two common examples of scaffolds constructed from natural materials. State three major components of ECM. 2 + 2 + 1
4. What is tissue engineering ? Mention the basic clinical goals and fundamental challenges of tissue engineering. 2 + 3
5. What is vasualization ? Describe the mechanism of basic wound healing. 2 + 3
6. Define the term “cellular differentiation”. Mention the basic properties of stem cell. 3 + 2
7. Describe different kinds of matrix materials used in tissue engineering. Mention the importance of growth factors in this field. 3 + 2
GROUP – C
( Long Answer Type Questions )
Answer any three of the following. 3 8 15 = 45
8. Define the term “angiogenesis”. Describe the process of angiogenesis along with chemical stimulants. Mention the current scope of development and therapeutics uses of tissue engineering. 3 + 6 + 6
9. Give a brief overview of receptor-ligand binding mechanism. Describe the signaling pathway for cell’s response to the ligand. What is cell surface marker ? 6 + 7 + 2
10. What is a Bioreactor ? Why is cell seeding important in a Bioreactor ? How do bioreactors function for engineering 3D-tissue construction ? 2 + 3 + 10
11. What do you understand by growth factors ? Cytokines are a unique family of growth factors — Justify. Classify growth factors based on their principal source and primary activity. 2 + 3 + 10
12. a) What are the basic aspects of wound healing ?
b) With the help of a suitable diagram, explain the different pathways for cell signalling. 5 + 10
13. Write short notes on any two of the following :
a) Transplant immunology
b) Cell preservation and storage
c) Cells for tissue engineering
d) Engineering tissues for bones and cartilages.
Tissue Engineering – 2012 :
Time Allotted : 3 Hours Full Marks : 70
** The figures in the margin indicate full marks.
** Candidates are required to give their answers in their own words as far as practicable.
GROUP – A : ( Multiple Choice Type Questions )
1. Choose the correct alternatives for the following : 10 × 1 = 10
(i) Pluripotent Stem cells are
a) Undifferentiated b) Differentiated
c) Adult Stem cells d) Matured cells.
(ii) Bleeding, Inflammation, Proliferation, Remodelling are phases of
a) Wound healing b) Clotting
c) Cell diferentiation d) Cell maturation.
(iii) An enzyme which adds phosphate to a protein is
a) Phosphatase b) Kinase
c) Dehydrogenase d) Reductase.
(iv) CAT codes for
a) Valine b) Alanine
c) Tryptophan d) Tyrosine.
(v) Blood is a
a) epithelial tissue b) connective tissue
c) nerve tissue d) none of these.
(vi) In-vivo tissue compartment are composed of ………. thick tissue slabs sandwiched by vasculature.
a) 50!µm
b) 100!µm
c) 150!µm
d) 200!µm.
(vii) Endocrine signaling is performed by
a) enzymes b) hormones
c) cytokines d) carbohydrates.
(viii) GABA is a
a) neurotransmitter b) neuroinhibitor
c) contact inhibitor d) contact excitator.
(ix) Solid Free Forming is a fabrication technique for
a) 2D scaffold
b) 3D scaffold
c) Microscaffold
d) Nanopatterned scaffold.
(x) The protein of cell that binds to a specific molecule is known as
a) ligand b) receptor
c) hormone d) cytokine.
GROUP – B : ( Short Answer Type Questions )
Answer any three of the following : 3 × 5 = 15
2. Write down the different steps of wound healing in detail. 5
3. What are growth factors ? Classify growth factors based on their function. 2 + 3
4. What are stem cells ? Differentiate between Embryonic and adult Stem Cells. 1 + 4
5. What is tissue engineering ? Mention the basic clinical goals and fundamental challenges of tissue engineering. 2 + 3
6. What do you mean by cell signaling molecules ? Briefly explain the different methods of cell-to-cell communication. 2 + 3
7. Give a brief overview of cellular adhesion and receptor-ligand binding. 5