Basic Sciences as Applied to Surgical Oncology M.Ch Question Bank : web.tnmgrmu.ac.in

Name of the University : The Tamilnadu Dr. M.G.R. Medical University
Degree : MASTER OF CHIRURGIAE (M.Ch.)
Branch : Branch VII – SURGICAL ONCOLOGY
Subject Code/Name : 1801/BASIC SCIENCES AS APPLIED TO SURGICAL ONCOLOGY
Paper : I
Document Type : Question Bank
Website : web.tnmgrmu.ac.in

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TNMGR Applied to Surgical Oncology Question Paper

Sub. Code: 1801
M.Ch. DEGREE EXAMINATION
(Higher Specialities)
(Revised Regulations)

Related : The Tamilnadu Dr. M.G.R. Medical University Basic Sciences Applied to Urology M.Ch Question Bank : www.pdfquestion.in/4566.html

Branch VII – SURGICAL ONCOLOGY
Paper I : BASIC SCIENCES AS APPLIED TO SURGICAL ONCOLOGY
Q.P. Code: 181801
Time: Three hours
Maximum: 100 Marks

August 2008

ANSWER ALL QUESTIONS :
Draw suitable diagrams wherever necessary. :
I. Essays: (2 x 20 = 40)
1. Describe the attributes of cancer preventing life style.
2. Discuss the cell cycle in oncology.
II. Write short notes on: (10 X 6 = 60)
1. Population based cancer registry.
2. Brachytherapy for cervical cancer.
3. Cancer trends in India.
4. MRI in cancer imaging.
5. Intraluminal ultrasound.
6. Radio sensitisers.
7. Anatomy of neck lymph nodes.
8. Physiology of ejaculation.
9. Isolated limb perfusion.
10. Mapping of sentinel node in breast cancer.

February 2009

I. Essays: 2 x 20 = 40 Marks
1. What is a PET scan? And role of PET scan in the diagnosis and follow up of cancer patients.
2. What is Ultrasonography? How intra operative ultrasonography is useful in cancer surgery with examples.
II. Write short notes on: 10 X 6 = 60 Marks
1. What is a tumor marker and it’s role in cancer diagnosis.
2. Phase III clinical trials.
3. Mohs microsurgery.
4. Discuss the physiology of Rectal continence.
5. Turban tumor.
6. Discuss on tumor suppressor genes with examples.
7. Turcot’s syndrome.
8. Interstial radiotherapy in cancer.
9. Describe the principle and indications of PDT.
10. What is a fibreoptic? And physics involved in of fibreoptic scopes in surgical practice.

August 2009

I. Essays: 2 x 20 = 40 Marks
1. Describe in detail the surgical anatomy of the liver. Briefly elaborate surgical procedures for hepatocellular carcinoma.
2. Describe principles involved in screening for cancer. Outline the evidence
for lung cancer screening.
II. Write short notes on: 10 X 6 = 60 Marks
1. RET Proto-oncogene.
2. Biases in medical research.
3. Role of palliative care in terminal cancer.
4. Nanotechnology – its role in cancer.
5. Isolated limb perfusion.
6. Phases of clinical trials.
7. HPV and cervical cancer.
8. Chemo prevention in head and neck cancer.
9. Genomics in cancer.
10. Institutional review board.

February 2010

I. Essays: 2 x 20 = 40 Marks
1. Discuss cell cycle, Ionising radiation, biological effects of radiation on normal and cancer tissues. Advantages of particle beam therapy.
2. Discuss in detail, the mechanism of action, mechanism of resistance, pharmacology of drug interaction, administration, toxicity and clinical uses of taxanes.
II. Write short notes on: 10 X 6 = 60 Marks
1. What is Photodynamic therapy? Discuss its mechanism and uses in cancer treatment.
2. Targeted chemotherapy.
3. Radio immuno guided surgery.
4. Intensity modulated radiotherapy.
5. Apoptosis and cell proliferation.
6. Pharmacokinetic rationale and limitations of regional chemotherapy.
7. Radiosensitisers.
8. Hyperfractionation.
9. Natural killer cell.
10. Meta analysis.

February 2011

I. Essays: (2 x 20 = 40)
1. Discuss the relationship between Diet and Cancer.
2. Discuss the biology of drug resistance in Cancer.
II. Write short notes on: (10 x 6 = 60)
1. Proteosome inhibitors.
2. Programmed cell death.
3. Physical carcinogens.
4. Split dose repair in Radiotherapy.
5. Immune escape.
6. Topoisomerase interacting agents.
7. Meta analysis.
8. Tyrosine kinase inhibitors.
9. Sumitib.
10. Anti-angiogenesis agent.

August 2011

I. Elaborate on : Pages Time Marks
1. Discuss the biological aspects of Radiotherapy.
2. Discuss the role of diet in cancer.

II. Write notes on :
1. Alkylating agents in chemotherapy.
2. Cohort study.
3. Stem cell therapy in cancer.
4. Cell cycle.
5. Passive immunological treatments.
6. Hospice care.
7. U.V. Radiation and cancer.
8. Radio frequency ablation.
9. Complications of chemotherapy.
10. AIDS and Cancer.

February 2012

I. Elaborate on : Pages Time Marks
1. Discuss about Viral carcinogenesis and cancer.
2. Discuss the principles of screening and the basis for developing and evaluating a cancer screening program.

II. Write notes on :
1. Pathophysiology of Cancer cachexia.
2. RET Proto-oncogene and thyroid cancer.
3. Comparative genomic hybridization.
4. Anti-angiogenic therapy in solid tumors.
5. Single nucleotide polymorphism.
6. Retinoic acid and cancer.
7. Linear Energy Transfer.
8. Prophylactic salpingo-oophorectomy.
9. Double strand breaks.
10. Levels of Evidence.

August 2012

Answer ALL questions in the same order.
I. Elaborate on : Pages Time Marks
1. Discuss the uses and advances in DNA microarray technology in cancer.
2. Discuss briefly about the hereditary predisposition to colorectal cancers and the impact of microsatellite instability (MSI).

II. Write notes on :
1. Elaborate on the association between VHL gene and Renal cell carcinoma.
2. Discuss the function and the clinical significance of Heat shock proteins.
3. Describe the pharmacokinetics of Capecitabine.
4. Elaborate on the role of tumor stroma interactions in tumor metastasis.
5. Discuss the biological basis of Fractionation in Radiotherapy.
6. Discuss the role of Adenomatosis polyposis coli (APC) gene in colorectal cancer.
7. Describe the statistical design of a Non inferiority trials.
8. Elaborate on the role of prophylactic thyroidectomy in medullary carcinoma thyroid.
9. Describe the mechanisms of cell cycle check points in genome maintanence.
10. Discuss the clinical significance of detection of circulating tumor cells in solid tumors.

February 2013

I.Elaborate on :
1. Discuss the Principles of combining Anti cancer agents with Radiotherapy
2. Discuss the role of Epigenetic biomarkers for early detection of cancer.

II.Write short notes :
1. Discuss the role of Waterfall plots in accessing clinical response
2. Discuss the significance of KRAS mutations in colorectal cancers
3. Pathogenesis of radiotherapy and chemotherapy induced oral mucositis
4. Discuss the molecular biology of Translocation associated sarcomas.
5. Pathway oriented models of Cancer Genome Analysis
6. Mechanisms of resistance to Tyrosine Kinase inhibitors.
7. Discuss the role of Anueploidy and Cancer
8. Discuss the issues concerning telomerase maintenance and cancer.
9. Role of Asbestos in the aetiopathogenesis of cancer.
10. Enumerate the surrogate markers for angiogeneic therapy.