Recent Advances in Haematology DM Question Bank : web.tnmgrmu.ac.in
Name of the University : The Tamilnadu Dr. M.G.R. Medical University
Degree : D.M
Branch : Branch X – Clinical Haematology
Subject Code/Name : 1404/RECENT ADVANCES IN HAEMATOLOGY
Paper : IV
Document Type : Question Bank
Website : web.tnmgrmu.ac.in
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TNMGRMU Clinical Haematology Question Paper
Sub. Code: 1404
D.M. DEGREE EXAMINATION
(Higher Specialities)
Branch X – Clinical Haematology
(Revised Regulations)
Paper IV : RECENT ADVANCES IN HAEMATOLOGY
Q.P. Code: 161404
Time: Three hours
Maximum: 100 Marks
Related : TNMGRMU Community Neonatology, Recent Advances DM Question Bank : www.pdfquestion.in/4510.html
August 2008
Answer ALL questions :
Draw suitable diagrams wherever necessary. :
I. Essays: 2 x 20 = 40
1. Monoclonal autibodies for treatment of haematological disorders.
2. Challenges and promises of gene theropy in severe haemophilic.
II. Write short notes on: 10 x 6 = 60
1. Prenatal diagnosis in haemophilia.
2. Enzyme replacement therapy in haematological disorders.
3. Application of extra corpuscular photopheresis.
4. Nuclic acid amplification test for blood safety.
5. Comparative Genomic hybridization.
6. Management of post transplant lympho proliferative disorders.
7. Recent advances in antifungal therapy.
8. Understanding the molecular mechanisam of haemophygocytic syndromes.
9. Eltrombopag and its application.
10. Management of imatinib resitance in CML in chronic phase.
August 2009
I. Essays: 2 x 20 = 40
1. AIDS related lymphomas.
2. Management of a female patient with 4 first trimester fetal losses.
II. Write short notes on: 10 x 6 = 60
1. Post exposure prophylaxis of HIV.
2. Platelet refractoriness.
3. Helicobacter pylori and ITP.
4. Role of Cytogenetics in MDS.
5. Granulocyte transfusions.
6. Management of Hemophilia A with inhibitors.
7. Infections in a BMT unit – preventive measures.
8. Arsenic trioxide.
9. Osteonecrosis of the jaw.
10. Eculuzimab.
August 2011
I. Elaborate on :
1. Discuss the management of philadelphia chromosome negative of adult acute lymphoblastic leukemia.
2. Describe the congenital marrow failure syndromes and discuss the management of Fanconi anemia.
II. Write notes on :
1. Hb H disease.
2. Decitabine.
3. Type 1 von Willebrand disease.
4. Hemophagocytic lymphohistiocytosis.
5. Molecular mechanisms of iron homeostasis.
6. Congenital neutropenia.
7. Disease monitoring in CML on treatment with tyrosine kinase inhibitors.
8. Induced pluripotent stem cells.
9. Dendritic cells.
10. Eculizumab.
August 2012
I. Elaborate on:
1. Discuss the pathophysiology, molecular and immune defects and diagnosis in children with congenital bone marrow failure syndromes.
2. Discuss in detail the diagnosis, prognostication and management of a 35 year old male with Acute Myeloid Leukemia.
II. Write Notes on:
1.Clofarabine.
2. Risk stratification of myelofibrosis.
3. Optimal frontline therapy for multiple myeloma.
4. Echinocandins.
5. Role of Hypomethylating agents in MDS.
6. Brentuximab.
7. Use of Rituximab in hematological disorders.
8. Role of 2nd generation TKI as first line therapy of CML.
9.Posaconazole.
10. Gene therapy.