Clinical Haematology DM Question Bank : web.tnmgrmu.ac.in

Name of the University : The Tamilnadu Dr. M.G.R. Medical University
Degree : D.M
Branch : Branch X – Clinical Haematology
Subject Code/Name : 1403/Clinical Haematology
Paper : III
Document Type : Question Bank
Website : web.tnmgrmu.ac.in

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Clinical Haematology Question :

August 2008 :
Sub. Code: 1403
D.M. DEGREE EXAMINATION

Related : TNMGRMU Laboratory Haematology DM Question Bank : www.pdfquestion.in/4499.html

(Higher Specialities)
Branch X – Clinical Haematology
(Revised Regulations)
Paper III – CLINICAL HAEMATOLOGY
Q.P. Code: 161403
Time: Three hours
Maximum: 100 Marks
Answer ALL questions :
Draw suitable diagrams wherever necessary. :
I. Essays: 2 x 20 = 40
1. What are the options in managing in a recently diagnosis BCR-Abl positive CML in a 25 yrs old male executive. The disease is in chronic phase and the patient has all the finance available for any kind of treatment.
2. How will you investigate and manage a female patient with warm antibody auto-immune haemolytic anaemia.
II. Write short notes on: 10 x 6 = 60
1. Leucocyte adhesion deficieny.
2. Juvenile chronic myeloid leukaemia.
3. Diagnosis of TTP and its differeniation from HUS.
4. Monoclonal gammopathy of unknown origin.
5. Parvovirus B19 associated marrow aplasia.
6. Use of bisphosphonates in haematological disorder.
7. How will you give prognosis in a case of multiple myeloma.
8. Non immunological hydrops.
9. Chronic synovitis in server haemophilic.
10. MLL gene translocation in haemoto oncology.

August 2009 :
I. Essays: 2 x 20 = 40
1. Describe the diagnosis and management of Waldenstroms macroglobulinemia.
2. Neonatal thrombocytopenia.
II. Write short notes on: 10 x 6 = 60
1. Management of transfusion overload.
2. Prothrombin deficiency.
3. Novel therapies for sickle cell disease.
4. Diagnosis of polycythemia vera.
5. Low molecular weight heparin.
6. Drug therapy for MDS.
7. Long term complications of stem cell transplant.
8. Anemia of chronic renal failure.
9. Prognostic markers in CLL.
10. L asparginase.

August 2011 :
I. Elaborate on :
1. Discuss the diagnosis, management and prevention of sickle cell disease.
2. A 10-year old child has a WBC count of 50,000/cu mm is suspected to have acute lymphoblastic leukemia. How will you confirm this diagnosis? What are the prognostic markers? What are the principles of management?
II. Write notes on :
1. Anemia in the neonate.
2. Graft versus host disease.
3. Platelet allo-immunization.
4. Hemorrhagic disease of the newborn.
5. Management of fixed flexion deformities of joints in Hemophilia.
6. Bernard Soulier syndrome.
7. Management of auto immune hemolytic anemia.
8. Management of amyloidosis.
9. Sezary syndrome.
10. Eltrombopag.

AUGUST 2012 :
I. Elaborate on:
1. Describe the pathophysiology, clinical manifestations and management of a patient with Paroxysmal Nocturnal Hemoglobinuria (PNH).
2. Describe the role of platelets in the formation of a hemostatic plug and discuss the classification and diagnosis of congenital platelet disorders.
II. Write Notes on:
1. Non-Transferrin Bound Iron (NTBI).
2. Pernicious anemia.
3. Clinical manifestations of G6PD deficiency.
4. Lenalidomide in MDS.
5. T regulatory cells.
6. MLL gene rearrangements in Acute Lymphoblastic Leukemia.
7. Treatment options for a patient with relapsed diffuse large B cell lymphoma.
8.Dasatinib.
9. Chronic Myelomonocytic Leukemia.
10. Diagnosis of hairy cell leukemia.

August 2013 :
I. Elaborate on : (2X15=30)
1. Describe how inhibitors form in severe haemophilia, the laboratory detection of inhibitors and the detailed management strategies in a patient with haemophilia and inhibitors.
2. Describe the pathophysiology, clinical findings, laboratory evaluation and management of cold agglutinin disease.

II. Write notes on : (10X7=70)
1. Diagnosis of fungal infection in neutropenic patients.
2. Hyperviscosity.
3. Prenatal diagnosis in haematological diseases.
4. Thrombocytopenia in pregnancy.
5. Risk stratification in CLL.
6. Factor V deficiency.
7. Severe combined immunodeficiency.
8. Donor lymphocyte infusion.
9. Purpura fulminans.
10. CMV infection.

August 2014 :
I. Elaborate on : (2 x 15 = 30)
1. Discuss the current diagnostic criteria and risk stratification in the management of bcr-abl negative myeloproliferative neoplasms.
2. Discuss the diagnosis, evaluation and management of a patient with deep vein thrombosis.

II. Write notes on : (10 x 7 = 70)
1. Ruxolitinib.
2. Thalidomide in haematology.
3. Discuss the management of blast crisis in CML.
4. Write a short note on relevance of BRAF mutations.
5. Management of anemia in patients with chronic renal failure.
6. Discuss role of Eltrombopag in the management of idiopathic thrombocytopenia.
7. Discuss in brief the current strategies to risk stratify acute myeloid leukemia.
8. Discuss in brief the currently used iron chelators and their relative advantages and disadvantages.
9. Omacetaxine.
10. Newer oral anticoagulants.