Basic Sciences in Radiation physics tumour biology, Biochemistry, Biometry, Immunology & Pharmacology DM Question Bank : web.tnmgrmu.ac.in

Name of the University : The Tamilnadu Dr. M.G.R. Medical University
Degree : D.M
Branch : Branch VII – Medical Oncology
Subject Name : 1301/BASIC SCIENCES (Radiation physics tumour biology, Biochemistry, Biometry, Immunology & Pharmacology)
Paper : IV
Document Type : Question Bank
Website : web.tnmgrmu.ac.in

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Basic Sciences in Radiation Physics Tumour Biology :

August 2008 :
Sub. Code: 1301
D.M. DEGREE EXAMINATION

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(Higher Specialities)
(Revised Regulations)
Branch VII – Medical Oncology
Paper I – BASIC SCIENCES
(Radiation physics tumour biology, Biochemistry, Biometry, Immunology & Pharmacology)
Q.P. Code: 161301
Time: Three hours
Maximum: 100 Marks
Answer ALL questions :
Draw suitable diagrams wherever necessary. :
I. Essays: 2 x 20 = 40
1. Discuss the current status of DNA microarray profiling in the management of malignant tumours.
2. Briefly outline the risk factors and pathogenesis of drug induced cardiotoxicity and its preventive strategies.
II. Write short notes on: 10 x 6 = 60
1. Erlotinib.
2. Clonal Evolution.
3. Acute Rejection
4. Partial breast irradiation.
5. Phase III clinical trial.
6. Information modelling.
7. Immunotoxins.
8. Steps in cancer drug development.
9. Continuous hyperfractionated. Accelerated radiation therapy.
10. Goldie – coldman hypothesis.

February 2009 :
I. Essays: 2 x 20 = 40
1. A 30 years old male has been diagnosed to have Hodgkin’s Lymphoma stage
II B. Discuss plan of investigations with rationale and briefly line of management.
2. Discuss briefly pharmacology of drugs used during the induction therapy of childhood acute lymphoblastic leukemia.
II. Write short notes on: 10 x 6 = 60
1. Newer Antiemetic drugs.
2. Advances in radiation therapy for thoracic cancer.
3. Survival plots.
4. Immunophenotyping for chronic lymphoproliferative disorders.
5. Biology of cancer cachexia.
6. Determination of Sample Size for a clinical trial.
7. K-ras mutations.
8. Venous thromboembolic complications of cancer.
9. PSA (Prostate Specific Antigen).
10. Molecular diagnosis of chimerism.

August 2009 :
I. Essays: 2 x 20 = 40
1. Describe the pathogenesis of tobacco induced cancers. Brief note on tobacco induced cancers.
2. Define angiogenesis, factors regulating angiogenesis and role of AntivegF in the management of lung cancer.
II. Write short notes on: 10 x 6 = 60
1. P53 gene.
2. HPV vaccines.
3. Apoptosis.
4. Dose intensity and dose density.
5. Image guided intervention in G.I. oncology.
6. Biomarkers in testicular tumor.
7. Bortesome (Protersome inhibitors).
8. I.M.R.T (Intensity Modulated Radiotherapy).
9. Tumor infiltrating hymphocytes.
10. Survellence – Tesicular tumor.

August 2011 :
I. Elaborate on :
1. Describe cancer cell kinetics and clinical application of chemotherapy, dose intensity and combination chemotherapy.
2. Predictive and prognostic molecular markers of pharmacogenomics and their application in clinical practice.
II. Write notes on :
1. Cancer stem cell and targeted therapy.
2. Ionising radiation and cancer.
3. Obesity and cancer.
4. Organ selective growth of metastases.
5. Toxicity of high dose interleukin.
6. Tyrosine kinase inhibitors.
7. Proteosome inhibitors in cancer treatment.
8. Molecular epidemiology.
9. Role of laparoscopy in management of Gynaecological Cancer.
10. Proteomics in cancer detection.

August 2012 :
I. Elaborate on : Pages Time Marks
1. Discuss in detail role of apoptosis in tumour progression. Briefly describe the drugs targeting the Bcl-2 family in Clinical Oncology.
2. Describe in detail the mechanisms of viral oncogenesis. Discuss the current status of HPV Preventive Vaccine strategies.

II. Write notes on :
1. Clinical indications and toxicity of sorafenib.
2. Role of ionising radiation in carcinogenesis.
3. Relevance of Proteomics in Cancer screening.
4. Electron Beam therapy and clinical indications.
5. Interim analysis and relevance in clinical trials in Oncology.
6. Smoking Cessation strategies.
7. Familial Adenomatous Polyposis syndrome.
8. Clinical Indications and Toxicity of Pemetrexed.
9. Principles of Cyberknife treatment and indications.
10. Role of Prophylactic surgery in Oncology.

February 2013 :
I. Elaborate on :
1 Discuss the role of Tumour markers in cancer with appropriate examples.
2. Give details on the role of the immune system in cancer development and discuss the approaches for cancer immunotherapy

II Write notes on :
1 Drug induced second malignancies including their management
2 Applications of Next generation sequencing in oncology
3 Molecular basis, clinical features and management of Li Fraumeni Syndrome
4 Indications, contraindications and basic principles of Stereotactic Radiosurgery
5 Molecular events involved in apoptosis
6 Pulmonary toxicity due to anti‐cancer agents
7 Management of drug extravasations
8 Tyrosine kinase receptors in cancer
9 Oncological applications of non‐ionizing radiation
10 Drugs acting on Topoisomerase including their toxicity

August 2013 :
I. Elaborate on :
1. Discuss the role of Tobacco in cancer including the mechanisms involved. Highlight the salient measures taken in our country to control tobacco use.
2. Discuss the types of ionizing radiation and their applications in oncological practice and their side effects.

II. Write notes on :
1. Fusion genes in solid tumours and their importance in oncological practice.
2. Quantitative Real Time PCR and its uses in oncology
3. Molecular basis, clinical features and management of PTEN Syndrome
4. Indications, contraindications and basic principles of Radioimmunotherapy
5. Molecular events involved in metastasis
6. Neuro-toxicity due to anti-cancer agents
7. TH1 versus TH2 response
8. DNA repair mechanisms
9. Immunodeficiency and cancer
10.Chemical carcinogens with examples