Applied Pharmacology & Forensic Pharmacology MD Question Bank : web.tnmgrmu.ac.in

Name of the University : The Tamilnadu Dr. M.G.R. Medical University
Degree : Doctor of Medicine (M.D.)
Branch : Branch VI – PHARMACOLOGY
Subject Code/Name : 2025/APPLIED PHARMACOLOGY AND FORENSIC PHARMACOLOGY
Paper : IV
Document Type : Question Bank
Website : web.tnmgrmu.ac.in

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Applied Pharmacology :

March 2009 :
[KU 128] Sub. Code: 2025
M.D. DEGREE EXAMINATION

Related : TNMGRMU Clinical Pharmacology & Pharmacotherapeutics Including Recent Advances MD Question Bank : www.pdfquestion.in/4286.html

Branch VI – PHARMACOLOGY
(Common to all candidates)
Paper IV – APPLIED PHARMACOLOGY AND FORENSIC PHARMACOLOGY
Q.P. Code : 202025
Time : Three hours
Maximum : 100 marks
Draw suitable diagram wherever necessary. :
Answer ALL questions. :
I. Essay questions : (2 x 20 = 40)
1. Discuss the structure activity relationship of opioids and opioid antagonists.
Briefly describe the pharmacology of newer mixed agonists and antagonists of opioid receptors.
2. Discuss the pharmacotherapy of first line drugs in the treatment of tuberculosis.
II. Write short notes on : (10 x 6 = 60)
1. Vasopeptidasse inhibitors.
2. Pharmacoepidemiology.
3. Newer macrolides.
4. Clinical pharmacology of antiemetics and prokinetic drugs.
5. Drug abuse in sports.
6. Drugs used in glaucoma.
7. Non compartmental pharmacokinetic analysis.
8. New treatments for anxiety disorders.
9. Nutraceuticals.
10. Pharmaological actions and potential therapeutic uses of melatonin.

September 2009 :
I. Essay questions : (2 x 20 = 40)
1. Describe the drugs affecting potassium channels and their clinical importance.
2. Describe the various types, their location, cellular mechanisms on stimulation, functions and antagonists of alpha receptors.
II. Write short notes on : (10 x 6 = 60)
1. Non renal drug elimination.
2. Clinical importance of perinatal pharmacology.
3. Different methods of preventing platelet aggregation.
4. Newer antiepileptic drugs.
5. Drugs inhibiting gastric acid secretion.
6. Drugs affecting central cholinergic transmission.
7. Newer developments in insulin administration.
8. Campothecins and taxanes as anti cancer agents.
9. Pharmaco economics.
10. Randomization and use of placebo in a drug trial.

March 2010 :
I. Essay questions : (2 x 20 = 40)
1. Indicate the site of action of diuretics and write how the site and mechanism correlate with clinical use.
2. How will you treat nosocomial infection due to multi drug resistant strain of: a) Staphylococcus aureus. b) Pseudomonas aeruginosa.
II. Write short notes on : (10 x 6 = 60)
1. Combination of 5- flucytosine and amphotericin – B.
2. How do you treat acute iron poisoning in a child?
3. Write treatment of poisoning due to strychnine.
4. Correlate the receptor activity with pharmacological action in case of opioids.
5. Haemodialysis.
6. Fast tracking in clinical research.
7. Phenobarbitone overdose.
8. Substance abuse in street children.
9. Toxicity of oestrogens.
10. Cyanide poisoning and treatment

Sub. Code: 2025
I. Essay questions : (2 X 20 = 40)
1. Discuss the methods to evaluate a newly designed antihypertensive drug in Humans.
2. Discuss the Newer Insulins’ and their use in clinical practice.
II. Write short notes on : (10 X 6 = 60)
1. Global Pharmacovigilance.
2. Anti obesity drugs.
3. Over the counter sale of drugs.
4. Drugs inhibiting platelet aggregation.
5. Phenobarbitone overdose.
6. Danazol.
7. Alprazolam over dosage.
8. Substance abuse.
9. Tamoxifen.
10. Insecticide poisoning and its treatment.

May 2011 :
I. Essay :
1. Discuss in detail mechanism of action of antidepressants.
2. Discuss the general principles of antimicrobial therapy.

II. Short Questions :
1. Therapeutic uses of ACE inhibitors.
2. Digitalis as an antiarrhythmic drug.
3. Mechanism of action of lithium.
4. Tobramycin.
5. Succimer.
6. Value of a toxicology laboratory in a hospital.
7. Probiotics.
8. Cyclosporine.

III. Reasoning Out :
1. Use of gonadotropin releasing hormone in treating infertility.
2. Use of beta adrenergic blockers in migraine.
3. Value of crossover design trials in drug trials.
4. Post-marketing surveillance of new drugs.

IV. Very Short Answers :
1. Mechanism of action of heparin.
2. James Black.
3. List adverse effects of Clindamycin.
4. List therapeutic uses of spectinomycin.
5. Calcimimetics.
6. Mechanism of action of propylthiouracil.
7. Adverse effects of sirolimus.
8. Mechanism of action of acyclovir.
9. List therapeutic uses of phenylephrine.
10. Mention adverse effects of clonidine.

April 2012 :
I. Essay:
1. Briefly describe the surveillance methods used in detecting adverse drug reactions?
2. Discuss the principles of Geriatric clinical pharmacology and therapeutics.

II. Short Questions :
1. Patient compliance.
2. Drugs offering anesthesia.
3. Mushroom poisoning.
4. Emergency contraception.
5. Performance enhancing drugs.
6. Nitric oxide.
7. Corrosive acid poisoning.
8. Chelation.

III. Reasoning Out :
1. Plumbism
2. Placental transfer of drugs and its importance.
3. Enzymes in therapy.
4. Mitotic spindle poisons.

IV. Very Short Answers :
1. What are drugs used in erectile dysfunction?
2. What is the importance of aging of enzyme?
3. Enumerate mood stabilizers.
4. Therapeutic advantage of GLP-I in diabetic mellitus.
5. Role of K channel openers in Angina pectoris.
6. Enumerate glycoprotein II b / III a Receptor antagonists.
7. Explain passive cumulation with example.
8. Natural products in cancer chemotherapy.
9. Rationale of ethanol in methanol poisoning
10. Enumerate the drugs produced by Recombinant DNA technology and their advantages.

April 2013 :
I. Essay :
1. Applied pharmacology of immunosuppresants
2. Role of drugs in the maintenance of calcium homeostasis

II. Short Questions :
1. Melatonin
2. Stem cell therapy
3. Therapeutic applications of botulinium toxin
4. Drug therapy of erectile dysfunction
5. Sunscreen
6. Alvimopan
7. HPLC
8. Nanoparticles in pharmacology

III. Reasoning Out :
1. Vasodilators in pulmonary arterial hypertension
2. Spironolactone in hypertension
3. Atropine in mushroom poisoning
4. Cheese reaction

IV. Very Short Answers :
1. Drugs and cosmetics act
2. Non analgesic use of opioids
3. Advantages of multidrug therapy
4. Jarisch-hexheimer reaction
5. Uses of methotrexate
6. Twilight sleep
7. Inhaled insulin
8. Drugs for amoebiasis
9. Thrombolytic agents
10.Oral Rehydration Therapy