Clinical Pharmacology & Pharmacotherapeutics Including Recent Advances MD Question Bank : web.tnmgrmu.ac.in

Name of the University : The Tamilnadu Dr. M.G.R. Medical University
Degree : Doctor of Medicine (M.D.)
Branch : Branch VI – PHARMACOLOGY
Subject Code/Name : 2024/Clinical Pharmacology & Pharmacotherapeutics Including Recent Advances
Paper : III
Document Type : Question Bank
Website : web.tnmgrmu.ac.in

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TNMGRMU Clinical Pharmacology Question Paper

[KU127] Sub. Code: 2024
M.D. DEGREE EXAMINATION
Branch VI – PHARMACOLOGY
(Common to all candidates)
Paper III – CLINICAL PHARMACOLOGY AND PHARMACOTHERAPEUTICS INCLUDING RECENT ADVANCES

Related : TN Dr. M.G.R. Medical University Neonatology, Developmental Paediatrics Preventive & Social MD Question Bank : www.pdfquestion.in/4288.html

March 2009

Q.P. Code : 202024
Time : Three hours Maximum : 100 marks
Draw suitable diagram wherever necessary. :
Answer ALL questions. :
I. Essay questions : (2 x 20 = 40)
1. Discuss how genetic factors influence drug effect with suitable examples.
2. Discuss the mechanisms of action, resistance, clinical uses, side effects and drug interactions of second generation flouroquinolones.
II. Write short notes on : (10 x 6 = 60)
1. Drug delivery in dermatological diseases.
2. Pharmaco economics.
3. Imatinib mesylate.
4. Drug utilization studies.
5. HRT advantages and disadvantages.
6. Role of placebo.
7. Glycoprotein IIa/IIIa inhibitors.
8. Drug resistance.
9. Drug therapy of Alzheimer’s disease.
10. Neuraminidase inhibitors.

September 2009

I. Essay questions : (2 x 20 = 40)
1. Describe the pharmacotherapy of major depressive illness.
2. Describe different phases of a clinical trial with particular reference to phase II trials.
II. Write short notes on : (10 x 6 = 60)
1. Pharmacogenomics
2. Selective dopamine, beta 1 and beta 2 agonists.
3. Compare nalbuphine and tramadol (Please tabulate)
4. Limitations of antiseptics.
5. Gene transfer.
6. Current status of phosphodiesterase III inhibitors.
7. Recent advances in anti HIV therapy.
8. Clinical importance of orders of kinetics.
9. Anti coagulants used in patients with heparin induced thrombocytopenia.
10. How to choose number of patients for a drug trial?

March 2010

I. Essay questions : (2 x 20 = 40)
1. Write in detail about the mechanisms and comparative pharmacology
of drugs used in rheumatoid arthritis.
2. Describe the recent advances in contraception.
II. Write short notes on : (10 x 6 = 60)
1. Amiodarone.
2. Prostaglandins as therapeutic agents.
3. Status of proton pump inhibitors in GIT diseases.
4. Biological response modifiers.
5. Fourth generation cephalosporins.
6. Triple drug regimens.
7. Protease inhibitors in HIV infections.
8. Role of 5 alpha reductase inhibitors and alpha blockers in detrusor sphincter dyssynergia.
9. Rationale of therapeutic utility of cholinergic drugs.
10. Present status of sympathomimmetics.

September 2010

Sub. Code: 2024
I. Essay questions : (2 X 20 = 40)
1. Discuss in detail about the drugs used in the treatment of Osteoporosis.
2. Discuss the therapeutic uses of Prostaglandins in obstetrics.
II. Write short notes on : (10 X 6 = 60)
1. Antiseptics.
2. Insulin resistance.
3. Topical antibacterial drugs.
4. Drugs in urinary tract disorders.
5. Radioactive isotopes.
6. Antiretroviral therapy.
7. Aspirin in clinical practice.
8. Antioxidants.
9. Rationale of therapeutic utility of cholinergic drugs.
10. Drugs used in preterm labour.

May 2011

[KY 127] Sub. Code: 2024
M.D. Degree Examination
Branch VI – Pharmacology
Clinical Pharmacology And Pharmacotherapeutics
Including Recent Advances
Q.P. Code : 202024
Time : 3 hours
Maximum : 100 marks (180 Min)
Answer ALL questions in the same order.
I. Essay:
1. Discuss in detail HIV protease inhibitors. 6 15 10
2. Write an essay on drug interactions. 6 15 10

II. Short Questions :
1. Drug targeting to the brain. 3 8 5
2. Sildenafil. 3 8 5
3. Role of triptans in migraine. 3 8 5
4. Dofetilide. 3 8 5
5. Tardive dyskinesia. 3 8 5
6. Selective estrogen receptor downregulators. 3 8 5
7. Adverse effects of lithium. 3 8 5
8. Ivermectin. 3 8 5

III. Reasoning Out :
1. Zafirlukast in asthma. 4 10 5
2. Oxybutinin in overactive bladder. 4 10 5
3. Methylphenidate in attention deficit hyperactivity disorder. 4 10 5
4. Thiazide diuretics in Diabetes insipidus. 4 10 5

IV. Very Short Answers :
1. Define International Normalized Ratio. 1 4 2
2. List adverse effects of zidovudine. 1 4 2
3. Name drugs for treating Torsades de pointes. 1 4 2
4. List therapeutic indications for 5-florouracil. 1 4 2
5. A.G. Gilman. 1 4 2
6. List therapeutic uses of probenicid. 1 4 2
7. List therapeutic uses of vancomycin. 1 4 2
8. List therapeutic uses of mannitol. 1 4 2
9. List therapeutic uses of nicorandil. 1 4 2
10. Mention clinical uses of Bacillus Calmette-Guerin (BCG). 1 4 2

April 2012

[LA 127] Sub. Code: 2024
M.D. Degree Examination
Branch VI – Pharmacology
Clinical Pharmacology And Pharmacotherapeutics
Including Recent Advances
Q.P. Code : 202024
Time : 3 hours
Maximum : 100 marks (180 Min)
Answer ALL questions in the same order.
I. Essay :
1. Current concepts in the management of Congestive Cardiac Failure. 9 15 10
2. Discuss in detail Antiretroviral agents in the treatment of HIV infection. 9 15 10

II. Short Questions :
1. Osmotic diuretics. 3 8 5
2. Finasteride. 3 8 5
3. Drugs modifying uptake mechanism. 3 8 5
4. Antitussives. 3 8 5
5. GnRH analogues. 3 8 5
6. Drug treatment of Benign Prostatic Hypertrophy. 3 8 5
7. Drugs modifying steroid Biosynthesis. 3 8 5
8. General toxicities of anticancer drugs. 3 8 5

III. Reasoning Out :
1. COMT inhibitors in parkinsonism. 5 10 5
2. Role of inhalational steroids in asthma. 5 10 5
3. Management of Paroxysmal supraventricular Tachyarrhythmia. 5 10 5
4. Drugs modulating GABA. 5 10 5

IV. Very Short Answers :
1. Mention the Keratolytic agent and their uses. 1 4 2
2. Mention progesterone Receptor modulators and their uses. 1 4 2
3. Drugs used in Pseudomonas infection. 1 4 2
4. Enumerate drugs modifying PABA. 1 4 2
5. What are the therapeutic uses of Ivermectin? 1 4 2
6. What is the mechanism of action of oral anti coagulants? 1 4 2
7. Write the common toxicities of amino glycosides. 1 4 2
8. Enumerate topical antibiotic and their uses. 1 4 2
9. Enumerate the selective COX2 inhibitors and their advantages.1 4 2
10. Name the opioid antagonists and the uses. 1 4 2