Systemic Pharmacology Including Recent Advances MD Question Bank : web.tnmgrmu.ac.in

Name of the University : The Tamilnadu Dr. M.G.R. Medical University
Degree : Doctor of Medicine (M.D.)
Branch : Branch VI – PHARMACOLOGY
Subject Code/Name : 2023/Systemic Pharmacology Including Recent Advances
Paper : II
Document Type : Question Bank
Website : web.tnmgrmu.ac.in

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TNMGRMU Systemic Pharmacology Question Paper

[KU 126] Sub. Code: 2023
M.D. DEGREE EXAMINATION
Branch VI : PHARMACOLOGY
(Common to all candidates)
Paper II – SYSTEMIC PHARMACOLOGY INCLUDING RECENT ADVANCES

Related :Tamilnadu Dr. M.G.R. Medical University Clinical Pharmacology & Pharmacotherapeutics MD Question Bank : www.pdfquestion.in/4286.html

March 2009

Q.P. Code : 202023
Time : Three hours
Maximum : 100 marks
Draw suitable diagram wherever necessary. :
Answer ALL questions. :
I. Essay questions : (2 x 20 = 40)
1. Outline the role of Nitric oxide in signal transduction in health and disease. List its implication for new drug development and pharmacotherapy.
2. Current status in pharmacotherapy of Parkinsonism.
II. Write short notes on : (10 x 6 = 60)
1. Write about canabinoid receptors. Add a note on canabinoids in the treatment of obesity.
2. Aprepitant.
3. Treatment of diabetic ketoacidosis.
4. Octreotide.
5. Cox – 2 inhibitor and colon cancer prevention.
6. Drug dosing schedule in health and disease.
7. Treatment of chloroquine resistant falciparum malaria.
8. Pharmaco kinetic principles of general anaesthesia.
9. Glycopeptide antibiotics.
10. Direct thrombin inhibitors.

September 2009

I. Essay questions : (2 x 20 = 40)
1. Describe the modification of GABA activity in the brain by drugs.
2. Describe the mechanism of action, spectrum and clinical uses of different generations of fluoroquinolones.
II. Write short notes on : (10 x 6 = 60)
1. Drugs for carcinoid syndrome.
2. Diuretic resistance.
3. Nitazoxanide.
4. Role of interferons in hepatitis.
5. Neuraminidase inhibitors.
6. Tyrosine kinase inhibitors.
7. Monoclonal antibodies in cancer chemotherapy.
8. Gonadotropins.
9. Drugs modifying adenyl cyclase function.
10. Recent advances in the pharmacotherapy of manic depressive psychosis.

March 2010

I. Essay questions : (2 x 20 = 40)
1. Discuss the pharmacology of dyslipidaemias.
2. Describe in detail the pharmacology of drugs used in Type II diabetes Mellitus giving importance to the combination therapy.
II. Write short notes on : (10 x 6 = 60)
1. Pleotrophic effects of statins.
2. Drug treatment of hypercalcemia.
3. Hypertensive emergencies.
4. Atypical antipsychotics.
5. Preanaesthetic medication.
6. Topical corticosteroids.
7. Adenosine.
8. Anastrazole.
9. Drugs used in cysticercosis.
10. Treatment of general toxicities encountered during anticancer therapy.

September 2010

Sub. Code: 2023
I. Essay questions : (2 X 20 = 40)
1. Discuss the Pharmacology of vasodilatory drugs used in therapeutics.
2. Discuss the clinically used drugs modifying the central excitatory neurotransmitters.
II. Write short notes on : (10 X 6 = 60)
1. Diuretic resistance.
2. Drug treatment of supraventricular arrythmias.
3. Rosuvastatin.
4. Pharmacokinetics of inhalation anaesthetics.
5. Potassium channel modulators.
6. Topical corticosteroids.
7. Fluoroquinolones.
8. Mechanism of action of antiepileptics.
9. Current trends of local anaesthetics.
10. Drugs used for induction of Ovulation.

May 2011

[KY 126] Sub. Code: 2023
M.D. Degree Examination
Branch Vi – Pharmacology
Systemic Pharmacology Including Recent Advances
Q.P. Code : 202023
Time : 3 hours
Maximum : 100 marks (180 Min)
Answer ALL questions in the same order.
I. Essay:
1. Discuss the pharmacotherapy of hyperlipidaemia. 6 15 10
2. Discuss the role of monoclonal antibodies in pharmacotherapeutics. 6 15 10

II. Short Questions :
1. Therapeutic uses of gonadotropins. 3 8 5
2. Repaglinide. 3 8 5
3. Blood brain barrier. 3 8 5
4. Therapeutic implications of circadian rhythms. 3 8 5
5. Progesterone receptor modulators. 3 8 5
6. Noncontraceptive health benefits of hormonal contraceptives. 3 8 5
7. Glucagon-like peptide 1. 3 8 5
8. Mechanism of action of tramadol. 3 8 5

III. Reasoning Out :
1. Advantages of selective COX-2 inhibitors. 4 10 5
2. Use of beta adrenergic blockers in heart failure. 4 10 5
3. Adrenocortosteroids as anti-inflammatory drugs. 4 10 5
4. N-acetlycysteine in paracetamol poisoning. 4 10 5

IV. Very Short Answers :
1. List therapeutic uses of thalidomide. 1 4 2
2. Mechanism of action of colchicine. 1 4 2
3. Mechanism of action of cyclophosphamide. 1 4 2
4. Adverse effects of nitrous oxide. 1 4 2
5. Mention therapeutic uses of dantrolene. 1 4 2
6. Mention adverse effects of succinylcholine. 1 4 2
7. List therapeutic uses of dobutamine. 1 4 2
8. Mention adverse effects of iron therapy. 1 4 2
9. List therapeutic uses of lignocaine. 1 4 2
10. List adverse effects of amphotericin. 1 4 2

April 2012

[KY 126] Sub. Code: 2023
M.D. Degree Examination
Branch Vi – Pharmacology
Systemic Pharmacology Including Recent Advances
Q.P. Code : 202023
Time : 3 hours
Maximum : 100 marks (180 Min)
Answer ALL questions in the same order.
I. Essay :
1. Discuss the recent advances in the treatment of Hypertension. 9 15 10
2. Current status in the pharmacotherapy of Parkinsonism. 9 15 10

II. Short Questions:
1. Tolperisone 3 8 5
2. Rosuvastatin 3 8 5
3. Low dose aspirin 3 8 5
4. Prokinetic drugs 3 8 5
5. Sitagliptin 3 8 5
6. Tocolytics 3 8 5
7. Uses and abuses of anabolic steroids 3 8 5
8. Atypical antipsychotics 3 8 5

III. Reasoning Out :
1. Role of angiotensin Receptor blockers in congestive cardiac Failure. 5 10 5
2. Drug combination in hyperlipedimics. 5 10 5
3. Benzodiazepines as sedative – hypnotic. 5 10 5
4. N – Acetyl cysteine in paracetamol poisoning. 5 10 5

IV. Very Short Answers :
1. Opioid Receptors sub types and their function. 1 4 2
2. Therapeutic and adverse effects of alpha blockers . 1 4 2
3. Advantages and disadvantages of Halothane. 1 4 2
4. Write the mechanism of action of oral anticoagulants. 1 4 2
5. Role of adrenaline in anaphylactic shock. 1 4 2
6. Rationale of pentazocine in Acute Myocardial Infarction. 1 4 2
7. Newer adjuvant therapy in osteoarthritis. 1 4 2
8. How will you manage obesity? 1 4 2
9. What is xenon? 1 4 2
10. Mention the endothelin antagonist and its therapeutic uses. 1 4 2