Natural Products Of Medicinal Interest M.Pharm Question Bank : web.tnmgrmu.ac.in

Name of the University : The Tamilnadu Dr. M.G.R. Medical University
Degree : M.Pharm DEGREE EXAMINATION
Subject Code/Name : 2907/Natural Products Of Medicinal Interest
Year : I
Paper : IV
Document Type : Question Bank
Website : web.tnmgrmu.ac.in

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MAY 2011 :
[KY 346] Sub. Code: 2907
M.PHARM. DEGREE EXAMINATION :
(Regulations 2010)
Candidates admitted from 2010-2011 onwards
BRANCH II : PHARMACEUTICAL CHEMISTRY
PAPER IV : NATURAL PRODUCTS OF MEDICINAL INTEREST
Q.P. Code : 262907
Time : Three hours
Maximum : 100 marks
Answer All questions :
I. Essay Questions : (6 x 10 = 60)
1. Write the application of IR, NMR and mass spectroscopy in the structural elucidation of natural product.
2. Enumerate the role of recombinant DNA Technology in drug discovery.
3. Write the general method of structural elucidation of alkaloids.
4. Write the synthesis and uses of reserpine.
5. Enumerate aminoglycoside antibiotics .Write any four compound.
6. Write the steroidal drug in plant constitution.
II. Write Short Notes : (8 x 5 = 40)
1. Write short note on psoralene.
2. Give an account of diosgenin.
3. Write note on antibody production.
4. Detail about oligonucleotide therapy.
5. Write SAR of penicillin.
6. Write the structure and uses of
a) clindamycin
b) Erythromycin
7. Outline the steps involved in preparation and purification of Insulin.
8. Explain the therapeutic applications of Swertia and phyllanthus niruri.

October 2011 :
I. Elaborate on :
1. Define alkaloid. Classify them with examples. Elucidate the structure of quinine.
2. (a) Explain the importance of GLC and HPLC in separation.
(b) Write in detail about currently used synthetic hormones.
II. Write notes on :
1. Give the application of IR in structural determination of natural products.
2. Explain the stereochemistry of steroids.
3. Explain the chemistry of rutin.
4. Explain briefly about Cepham and Penam ring systems.
5. Degradation of Penicillin’s.
6. Give the general structural elucidation of Terpenoids.
7. Give an account of DNA technology.
8. Explain the chemistry of Psorlene.
9. Explain the role of Gymnema sylvestre.
10. Macrolide antibiotics.

MAY 2012 :
I. Elaborate on:
1. (a) Discuss the salient features involved in the isolation, identification and purification of terpenoids.
(b) Explain the application of IR, NMR, MAS, CD and ORD in the structural elucidation of terpenoids.
2. (a) Give a detailed account of the structural elucidation of cholesterol.
(b) Write a note on cardiac sugars.
II. Write notes on:
1. Briefly explain the chemistry of rutin.
2. Outline the mechanism of beta – lactamase inhibitors.
3. Write a note on cannabinoids.
4. Outline the various methods adopted to clone fragments of DNA.
5. Discuss the synthetic modifications and S.A.R. of macrolides.
6. Enumerate and write the significance of pharmaceutical products based on rDNA technology.
7. Explain the structural constitution of reserpine.
8. Write briefly on the natural products used as antitumour agents.
9. Give the structure and uses of five currently used glucocorticoids.
10.What is P-UVA? Write the chemistry of xanthotoxin.

NOVEMBER 2012 :
I. Elaborate on :
1. a) Give the structural elucidation of Reserpine.
b) Discuss in detail about Terpenoids.
2. Give the structural elucidation of sterols.
II. Write notes on :
1. Cephalosporins.
2. Polypeptide antibiotics.
3. Write notes on the drugs used in indigenous System
or Antitumour & liver.
4. What are antibodies? Write about them.
5. Transformation of phytosterols into steroidal drugs.
6. Quercetin.
7. Cannabinoids.
8. Application of HPLC to plant constituents.
9. Aminoglycosides.
10. Semi synthetic pencillines.