GTU Current Semester B.Pharm Exam Paper 2018 : Gujarat Technological University
Board: Gujarat Technological University
Exam : B.Pharm – Semester–1 Examination
Subject : Pharm Chemistry-I
Document Type : Current Semester Exam Paper
Website : https://www.gtu.ac.in/Download1.aspx
GTU B.Pharm Current Semester Exam Paper
Download Question Paper of B.Ph. – Semester–1 Examination 2018 Sample Question is now available in the official website of Gujarat Technological University.
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Instructions
1. Attempt all questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks
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Model Questions
Time : 10:30am to 01:30pm
Total Marks : 80
Pharm Chemistry-I
Q.1 (a) Classify gastrointestinal agents. Write a note on milk of magnesia. 06
(b) Write a note on chelating agents used in therapy. 05
(c) What are antacids? Outline the ideal requirements of an antacid. 05
Q.2 (a) Discuss the source of impurities in pharmaceutical substances. 06
(b) Write a note on anti-oxidant. Explain preparation and uses of sodium thiosulphate. 05
(c) Discuss physiological acid base balance. 05
Q.3 (a) What are anticaries agents? Discuss the role of fluoride. 06
(b) Define antidote. Give properties and preparation of sodium nitrite. 05
(c) Write in detail about different types of water. 05
Q.4 (a) Write a note on geiger muller counter. 06
(b) Give principle of limit test of iron and lead. 05
(c) Write a short note on Respiratory stimulants and Expectorants. 05
Q.5 (a) Define and classify topical agents with suitable examples. Give preparation, properties, uses and assay principle of Zinc oxide. 06
(b) Give a brief account on Oral Rehydration salt. 05
(c) Write a note on Indian Pharmacopeia. 05
Q. 6 (a) What do you mean by antibacterial agents? Explain its mechanism. Give the properties, assay principle and uses of AgNO3. 06
(b) What is buffer? Define about the buffer action. 05
(c) Write a note on biological significance of calcium. 05
Q.7 (a) Write the preparation and uses of Aluminum hydroxide gel, sodium fluoride, and copper sulphate. 06
(b) Write the storage conditions for carbon dioxide, hydrochloric acid and potassium bromide. 05
(c) Write composition of various iodine preparations. 05
Pharmaceutical Engineering
Q.1 (a) Discuss in details about unit operations and Dimensional equation with their pharmaceutical significances. 06
(b) Write a note on Tie- substance and Energy balance. 05
(c) Explain about methods for Grahical presentations. 05
Q.2 (a) Discuss in details about Bernoulli’s theorem and give it’s applications 06
(b) Write a note on Rotameter and Orifice meter 05
(c) Differentiate between Pitot tube and venturi meter 05
Q.3 (a) Classify different types of valve. Explain Diaphragm valve with suitable diagram. 06
(b) Compare the characteristics of Reciprocating and Centrifugal Pumps 05
(c) Give the differences between pipes and tubing. 05
Q.4 (a) Describe principle and working of rotameter with labeled diagram. 06
(b) Write about laws: Dalton’s Law and Amagat’s Law 05
(c) Clasify manometers with advantages and dis advantages. Discuss about Inclined Manometers 05
Q.5 (a) Enumerate different types of heat exchange equipment. Discuss construction and working of single pass tubular heatexchanger06
(b) Define conduction. Write a note on Fourrier’s law 05
(c) Discuss in breif about Black body and Grey body. 05
Q. 6 (a) Explain various factors affecting on selection of materials for plant construction. 06
(b) What are the differences between pipes and tubing? 05
(c) Explain about Plastics used in Pharmaceutical industries with their merits and de-merits. 05
Q.7 (a) How to prevent and control of different types of corrosion in industry. 06
(b) Enlist different types of conveyor. Write in details with a diagram onBucket conveyer. 05
(c) Write a short note on solid/fluid mass transfer 05
Pharmaceutics – I
Q.1 (a) Discuss rotary drum filter in detail. 06
(b) What are the mechanisms of filtration? Discuss in detail. 05
(c) Write a note on cartridge filters. 05
Q.2 (a) Discuss theory on centrifugal effect. 06
(b) Write principle, construction and working of perforated basket centrifuge. 05
(c) Differentiate filtration and centrifugation. 05
Q.3 (a) Write a note on filter aid. 06
(b) Discuss the factors affecting evaporation. 05
(c) Describe the multiple effect evaporators with labeled diagram. 05
Q.4 (a) Define fractionation and discuss the fractionating columns with diagram. 06
(b) Give short note on azeotropic distillation with examples. 05
(c) Discuss the molecular distillation in detail. 05
Q.5 (a) Write a note on theory and mechanisms on drying. 06
(b) Give a note: Fluidized bed dryer.05
(c) Define the terms EMC, CMC, drying rate, moisture content and % LOD.05
Q. 6 (a) Give note on compression refrigeration cycle with diagram. 06
(b) Describe Wet bulb- Dry bulb method to determine humidity. 05
(c) Give short note on Air Handling Unit. 05
Q.7 (a) Discuss the psychometric chart and its parameters. 06
(b) Discuss the refrigeration cycle.05
(c) Write principle, working and merits-demerits on spray dryer. 05
Human Anatomy Physiology
Q.1 (a) Classify Epithelial Tissue? Add a note on Simple Epithelium. 06
(b) Describe mechanism of protein synthesis by cell organelles. 05
(c) Describe process of digestion and absorption of carbohydrates. 05
Q.2 (a) Classify Joints with example? Add a note on Synovial Joint. 06
(b)Write on types and functions of WBC. 05
(c) Describe anatomy and physiology of liver. 05
Q.3 (a) What is anemia? Explain various anemia in detail. 06
(b) Give the composition and formation of Lymph and discuss its functions. 05
(c) Write a note on: Blood groups and its significance. 05
Q.4 (a) Draw a labeled diagram of neuromuscular junction. Write a detailed note on physiology of muscle contraction. 06
(b) Explain regulation of gastric secretion and motility.05
(c) Define blood pressure. Explain the role of rennin- angiotensin system in regulation of blood pressure. 05
Q.5 (a) Draw neat and well labeled diagram of heart. Explain in detail the conduction system of heart. 06
(b) Define immunity. Describe the role of B-lymphocyte in immunity. 05
(c) Write a short note on ECG. 05
Q. 6 (a) Enumerate clotting factors and explain the clotting process in detail. 06
(b) What is cardiac output? Describe the factors affecting cardiac output. 05
(c) Describe composition and process of bone formation.05
Q.7 (a) Classify transport mechanism across cell membrane. Explain each of them with suitable examples. 06
(b) Write a note on reticulo-endothelial system. 05
(c) Draw a labeled diagram of neuron. 05
Therapeutic Drug Monitoring
Q.1 (a) Explain following terms:
(I) Bioequivalence.
(II) First pass clearance.
(III) Relative bioavailability. 06
(b) Explain physicochemical factors affecting bioavailability. 05
(c) Enlist theories of dissolution and explain any one in detail. 05
Q.2 (a) What is TDM? Give its uses and recommendations. 06
(b) Explain in brief collection and storage condition of body fluid samples. 05
(c) Explain in detail radio immunoassay method. 05
Q.3 (a) Explain following techniques for in TDM of valproic acid:
(I) Sample collection.
(II) Time of sample collection. 06
(b) Explain following techniques for in TDM of phenytoin:
(I) Usual dosing parameters.
(II) Clinical monitoring parameters. 05
(c) Explain following techniques for in TDM of Immunosuppressants:
(I) Common toxicities.
(II) Drug reaction and interactions. 05
Q.4 (a) Explain in brief techniques for enhancing bioavailbility. 06
(b) Write a short note on in vivo-in vitro correlation studies. 05
(c) Enlist pharmocodynamic models. Explain any one in detail. 05
Q.5 (a) What are the criteria for selection of method for TDM? Explain in brief sample related parameters. 06
(b) Enumerate elements of bioequivalence study protocol. Explain any one in detail. 05
(c) Enlist physical methods used in TDM. Explain any one in detail. 05
Q. 6 (a) Write a short note on role of clinical pharmacist in TDM. 06
(b) Explain in detail ELISA Immuno assay. 05
(c) What is the objective of BA studies? 05
Q.7 (a) Enumerate immunoassay methods used in TDM. Explain FPIA in details. 06
(b) Give a full form of following terms: (I) HPLC (II) HPTLC (III) GC (IV) EMITH (V)TDM 05
(c) Write a short note on study of clinical pharmacokinetics and importance parameters for lidocaine. 05
Food Analysis
Q.1 (a) Write short note on Gel electrophoresis. Give its applications. 06
(b) Write Short note on analysis of pesticides in food. 05
(c) Write Short note on ultra centrifugation technique. Give its applications. 05
Q.2 (a) Define spectroscopy. Explain Beer-Lambert law. Give applications of UV spectroscopy in food analysis. 06
(b) How the Mass spectroscopy & NMR spectroscopy are useful in food analysis? 05
(c) Write a note on standards for food additives 05
Q.3 (a) Explain the techniques used to determine starch products and preservatives in food products. 06
(b) Describe the various methods for analyzing various proteins in food products 05
(c) Write short note on stability study of food products. 05
Q.4 (a) Define chromatography. Explain HPLC. How it is useful in food analysis? 06
(b) What is genetically modified food? Write short note on how genetically modified food is analysed? 05
(c) Write short note on flash chromatography. 05
Q.5 (a) Explain responsibilities of food business operator.06
(b) Define the following as per food safety and standard act:
1. Food 4. Food additive
2. Extraneous matter 5. Misbranded food
3. Adulterant 6. Ingredients 05
(c) Write short note on Scientific committee. Explain procedure for Scientific Committee and Scientific Panel. 05
Q. 6 (a) Write short note on Duties and functions of Food Authority. 06
(b) Write short note on detection of toxic trace metals & insect infestation in food sample. 05
(c) Define moisture content. Enlist different techniques used for determination of moisture content. Explain evaporation technique in detail. 05
Q.7(a) Define ash content. Explain how the ash content is determined in food sample. 06
(b) Enlist general chemical and instrumental methods food analysis. Explain any one method in detail with its application. 05
(c) Write short note on food contaminants. 05
Genetic Engineering
Q.1 (a) Write applications of genetic engineering. 06
(b) Explain gene organization in cell.05
(c) Explain synthesis of cDNA.05
Q.2 (a) Explain the methods used for isolation of RNA. 06
(b) Explain about DNA modifying enzymes. 05
(c) Write a note on transformation. 05
Q.3 (a) Enumerate the types of vectors. Explain any one vector in detail with diagram. 06
(b) Write in detail about gene cloning with neat labeled diagram. 05
(c) Write short note on Transgenic plants. 05
Q.4 (a) What is PCR? Explain applications of PCR in detail. 06
(b) Write a short note on handling and quantification of nucleic acids. 05
(c) Enumerate different of DNA sequencing. Explain any one method of DNA sequencing in detail with suitable diagram. 05
Q.5 (a) What are monoclonal antibodies? How they are produced using the techniques of genetic engineering? 06
(b) Explain PCR cycle in detail.05
(c) Explain about DNA vaccines against Cancer.05
Q. 6 (a) Write a note on Automatic DNA sequence. 06
(b) Write about r-DNA technology in treatments of medical conditions. 05
(c) Write short note on gene therapy for hematopoietic disorders,05
Q.7 (a) Write a note on antisense- oligonucleotide therapy. 06
(b) Write short note on gene therapy for Neurological Diseases. 05
(c) Discuss blotting techniques in detail. 05