Name of the University : Mahatma Gandhi University
Department : Chemistry
Degree : M.Sc. Pharmaceutical Chemistry
Subject Code/Name : PH3C09/Synthetic & Bioorganic Chemistry
Sem : III
Website : mgu.ac.in
Document Type : Model Question Paper
Download Model/Sample Question Paper : https://www.pdfquestion.in/uploads/mgu.ac.in/5118-III%20PH.pdf
Synthetic & Bioorganic Chemistry Question :
Third Semester M.Sc. Pharmaceutical Chemistry :
Model Question Paper :
Time: Three hours
Related : MGU CH3C11 Chemical Kinetics, Surface Chemistry & Photochemistry M.Sc Model Question Paper : www.pdfquestion.in/5111.html
Total Weight: 30
Section A :
(Answer any 10 questions. Each question carries a weight of 1)
01. Give examples of chromium and silver based oxidation of alcohols to carbonyl compounds.
02. Discuss any two methods for the synthesis of diols from alkenes using Osmium.
03. What is Tebbe olefination?
04. What is Baylis-Hilman reaction? Explain its mechanism.
05. What is DIBAL-H? Give any two applications of DIBAL-H.
06. Explain Noyori asymmetric hydrogenation.
07. What is Nef reaction? Explain its mechanism.
08. Discuss Birch reduction.
09. Give two examples of metal based reductions using Li in ammonia.
10. Explain aza-Cope rearrangement.
11. How are alkaloids classified?
12. What is MPV reduction? Give one example.
13. Give the synthesis of beta carotene.
(10×1=10 weights)
Section B :
(Answer any 5 questions. Each question carries a weight of 2)
14. Discuss the method of synthesis of epoxide from alkenes. Explain the mechanism of Sharpless asymmetric epoxidation.
15. Discuss the photochemical approaches for the synthesis of oxetanes.
16. Explain the method of construction of macrocyclic rings by ring closing metathesis.
17. Discuss the mechanism and applications of inter and intra molecular ketene cycloaddition.
18. How will you synthesize esters and lactones from ketones? Explain Baeyer-Villiger oxidation.
19. Write note on synthesis of progesterone.
20. Explain the mechanism of host-guest complex formation. Comment on the forces involved in molecular recognition.
21. Discuss the green alternatives of organic synthesis with special reference to electrophilic aromatic substitution reactions. (5×2=10 weights)
Section C :
(Answer any 2 questions. Each question carries a weight of 5)
22. Discuss the structure elucidation and synthesis of papaverine.
23. Write an essay on metal mediated C-C and C-X coupling reactions with special reference to
(a) Suzuki coupling, (b) Heck reaction, (c) Ullmann reaction, (d) Nozaki-Hiyama reaction.
24. Discuss the stereoselective synthesis of tri and tetra substituted olefins.
25. What are molecular receptors? Explain the structure, functions, and applications of the following as receptors.
(a) cyclodextrins, (b) crown ethers, (c) cryptands, (d) tweezers, (e) crown ethers (2×5=10 weights)
Core Course : CH5B01- Chemistry of d and f block elements
Model Question Paper :
Time : 3 Hours Total
Weightage : 25
Section A :
(Answer all questions .A bunch of four questions carries weightage of 1)
I ** The first transition series begins with ———————–
** Zn, Cd, Hg ions are colourless because they have ————— electronic configuration
** Maximum oxidation state shown by manganese is ——————
** EAN of iron in Fe(CO)5 is —————
II ** ——————- is often called muscle Hb
** Oxidation state of a metal in metal carbonyl is ———————
** The general electronic configuration of lanthanides is —————–
** Hexafluorocbalt(III) ion is a ——————— complex
III ** IUPAC name of the complex K[Ag(CN)2] is ——————
** Vitamin B12 is a complex of ————— metal
** Dimethylglyoxime is used to identify —————– metal ion
** The royal blue colour of [Re2Cl8]2- is due to —————— transition
IV ** In coordination compounds the negative groups or neutral molecules attached to central metal atom are called ———————-
** Give an example for dihapto ligand
** Most common oxidation state of actinides is —————–
** The overlap of the filled metal orbital with the vacant molecular orbitals of ligand in organometallic compounds is called ———— bonding
Section B : (Answer any five questions. Each question carries weightage of 1)
** Point out the differences between double salts and coordination compounds
** Cu(I) is diamagnetic while Cu(II) is paramagnetic. Why?
** What is lanthanide contraction?
** Give the structure of Ni(CO)4.
** Write the role of Zn in biochemistry
** What is Wilkinson’s catalyst?
** Explain ambidentate ligand. Give an example
** What is Na/K pump?
Section C : (Answer any four questions. Each question carries weightage of 2)
** Why do transition metals show variable valency?
** Mention the factors affecting stability of a complex
** Why [Ni(CN)4]2- diamagnetic and square planar?
** What are high spin and low spin complexes?
** Lanthanides and actinides are placed separately in the periodic table. Why?
** Write a note on Zeigler- Natta catalyst