Name of the University : The Tamilnadu Dr. M.G.R. Medical University
Degree : D.M
Branch : Branch X – Clinical Haematology
Subject Code/Name : 1402/Laboratory Haematology
Paper : II
Document Type : Question Bank
Website : web.tnmgrmu.ac.in
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Laboratory Haematology Question Bank :
August 2008 :
Sub. Code: 1402
D.M. DEGREE EXAMINATION
Related : TNMGRMU Structure & Function of the Haemopoietic System, Molecular Biology & Genetic Aspects Of Haemopoiesis DM Question Bank : www.pdfquestion.in/4495.html
(Higher Specialities)
Branch X – Clinical Haematology
(Revised Regulations)
Paper II – LABORATORY HAEMATOLOGY
Q.P. Code: 161402
Time: Three hours
Maximum: 100 Marks
Answer ALL questions :
Draw suitable diagrams wherever necessary. :
I. Essays: 2 x 20 = 40
1. Describe the laboratory approach for the diagrams of haematological causes of central cyanosis.
2. What are the principles of measuring an important analyte by ELISA technique. What are the different types of ELISA used in haematological laboratory.
II. Write short notes on: 10 x 6 = 60
1. Laboratory diagnosis of platelet refractoriness.
2. Laboratory diagnosis of DCT negative immune haemolytic anaemia.
3. Application of lectins in haematology laboratory.
4. JAK 2 mutation in haemotological disorder.
5. Separation of cells by density gradient.
6. Principles of staining a standard periphnal smear by Romanowsky based panchromatic stain.
7. Laboratory diagnosis of foeto maternal haemorrhage.
8. Principles of assuring platelet function in the laboratory.
9. FISH in diagnosis of haematological disorders.
10. How do you demonstrate ring sideroblasts? Describe the principles of staining for ring sideroblasts.
August 2009 :
I. Essays: 2 x 20 = 40
1. Describe investigations for the diagnosis of multiple myeloma; mention in brief their principle, methods and significance.
2. Describe the peripheral blood smear in health and disease.
II. Write short notes on: 10 x 6 = 60
1. Lupus anticoagulant.
2. PFA 100.
3. Automated reticulocyte count.
4. Flowcytometry in the diagnosis of chronic lymphoproliferative disorders.
5. Soluble transferring receptors (STIR).
6. Vitamin B12 and folate assay.
7. TPMT.
8. Cytogenetic in Fanconi’s anemia.
9. MRD detection in acute leukemia.
10. PH Chromosome.
August 2011 :
I. Elaborate on :
1. Discuss the tests used in the laboratory evaluation of a 28 year old lady with 1 week old femoral venous thrombosis. What precautions would you take in performing these tests in relation to this patient?
2. What measures would you adopt to evaluate and select a cell counter? How will you develop and validate your decision rules for slide review on the cell count samples sent to the lab?
II. Write notes on :
1. The flow cytometric analysis of chronic lymphoproliferative disorders.
2. Congenital non-spherocytic haemolytic anemia.
3. Transfusion associated graft versus host disease (TA-GVHD).
4. Laboratory basis of neonatal alloimmune thrombocytopenia.
5. Hb A2 – measurement and interpretation of results.
6. Laboratory diagnosis of malaria.
7. Measurement of ADAMTS-13 and its significance.
8. Laboratory methods to document the bcr-abl translocation.
9. Romanowsky – Giemsa effect.
10. Laboratory diagnosis of heparin induced thrombocytopenia thrombosis.
AUGUST 2012 :
I. Elaborate on:
1. Describe in detail the laboratory evaluation of a patient with suspected von Willebrand disease.
2. A 50 year old man presents with weakness and pancytopenia. There are features of dysplasia in the white cells. Describe in detail the laboratory evaluation of this patient.
II. Write Notes on:
1. Etiology and laboratory diagnosis of megaloblastic anemia.
2. Hereditary pyropoikilocytosis.
3. Autohemolysis test.
4. Stress cytogenetics.
5. Chimerism analysis following stem cell transplant.
6. Coomb’s test.
7. Romanowsky stains.
8. Cytogenetic abnormalities in multiple myeloma.
9. Detection of minimal residual disease in leukemia.
10. Utility of flow cytometry in platelet disorders.
August 2013 :
I. Elaborate on :
1. Describe the laboratory evaluation of a patient with suspected platelet function disorder.
2. Describe in detail the laboratory evaluation of a patient with aplastic anaemia.
II. Write notes on :
1. Methods of HLA typing.
2. Diagnosis of methaemoglobinemias.
3. Diagnosis of heparin induced thrombocytopenia.
4. Flowcytometry in red cell disorders.
5. Molecular markers in AML.
6. Free light chain assay.
7. Sequencing.
8. Perl’s stain.
9. Evaluation of platelet refractoriness.
10. Diagnosis of leukocyte adhesion defects.
August 2014 :
Answer ALL questions in the same order.
I. Elaborate on :
1. Enumerate methods of CD34 quantification, its relevance and the quality control measures used for these assays.
2. Discuss the diagnosis and classification of Von Willebrand disease.
II. Write notes on :
1. Laboratory methods to classify diffuse large B cell lymphoma.
2. T315 I mutation in CML.
3. Diagnostic tests and their limitations in Paroxysmal Nocturnal Haemoglobinuria.
4. Write briefly on methods used, their advantages and disadvantages, in ‘Minimal Residual Disease’ (MRD) detection of ALL.
5. Write a brief note on tests used in the diagnosis of Thrombotic Thrombocytopenic Purpura.
6. Write a brief note on evaluation of a suspected red cell enzymopathy.
7. Discuss the mutation profile of myeloproliferative neoplasms.
8. Discuss the role of molecular monitoring in the management of chronic myeloid leukemia.
9. Write a short note on laboratory investigations in a suspected case of anemia of chronic disease.
10. Write a short note on FLAER.