Name of the University : The Tamilnadu Dr. M.G.R. Medical University
Degree : D.M
Branch : Branch IV – GASTROENTEROLOGY
Subject Name : 1251/Basic Sciences Applied To Gastroenterology
Paper : I
Document Type : Question Bank
Website : web.tnmgrmu.ac.in
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Basic Sciences Applied to Gastroenterology :
August 2008 :
Sub. Code: 1251
D.M. DEGREE EXAMINATION
(Higher Specialities)
Related : TNMGRMU Hepatobiliary,Pancreatic Diseases DM Question Bank : www.pdfquestion.in/4411.html
Branch IV – GASTROENTEROLOGY
(Revised Regulations)
Paper I – BASIC SCIENCES APPLIED TO THE SPECIALITY
Q.P. Code: 161251
Time: Three hours
Maximum: 100 Marks
Answer ALL questions :
Draw suitable diagrams wherever necessary. :
I. Essays: 2 x 20 = 40
1. Discuss briefly the embryonic development of esophagus and various developmental anomalies of esophagus.
2. Describe the anatomy of sphincter of oddi. Give a detail account of sphincter of oddi dysfunction.
II. Write short notes on: 10 x 6 = 60
1. Gastric volvulus.
2. Ghrelin.
3. Gut neuropeptides.
4. Anorectal manometry.
5. Night eating syndrome.
6. Choledochal cysts.
7. Hepatic venous pressure Gradient.
8. Segments of liver.
9. Annular pancreas.
10. Secretary IgA.
August 2009 :
I. Essays: 2 x 20 = 40
1. Discuss physiology of gastric secretion and role of receptor blockers.
2. Discuss the digestion and absorption of fat and tests of fat mal absorption.
II. Write short notes on: 10 x 6 = 60
1. Paneth cell.
2. Matrix metalloproteinase.
3. Rappaports acinus.
4. Gluten.
5. Serology in inflammatory bowel diseases.
6. Bilirubin Metabolism.
7. Hepatitis ‘B’ virus envelope antigen.
8. Alkaline phosphatase.
9. Ig A and gut.
10. Hiatus hernia.
February 2011 :
I. Essays: 2 x 20 = 40
1. Functional Anatomy of Gut-Associated Lymphoid Tissue and discuss current pathogenesis of IBD.
2. Describe the hepatocyte with suitable diagrams and how to approach a patient with elevated Alkaline phosphatase level.
II. Write short notes on: 10 x 6 = 60
1. Hepatic Fibrosis.
2. Prothrombin Time.
3. Terlipressin.
4. Gastric Pacemaker.
5. Short chain fatty acids.
6. DNA Repair genes.
7. Proton pump inhibitors.
8. Assessment of gastric neuromuscular function.
9. Ghrelin.
10. Pharmacotherapy for obesity.
August 2011 :
I. Elaborate on :
1. Describe the composition and function of pancreatic juice and discuss the role of pancreatic function tests.
2. Describe the normal bacterial flora of gut and discuss the
role of probiotics.
II. Write notes on :
1. Peyer’s patches.
2. Oncofetal proteins.
3. Kwashiorkor.
4. Celiac disease.
5. Percutaneous endoscopic gastrojejunostomy.
6. Sibutramine.
7. Vertical banded gastroplasty.
8. Binge eating disorder.
9. Eosinophilic proctocolitis.
10. Dermatitis Herpetiformis.
February 2012 :
I. Elaborate on : Pages Time Marks
1. Pathogenesis, investigations and treatment of gastric cancer.
2. Causes, clinical evaluation and investigations of obstructive jaundice.
II. Write notes on :
1. Secondary prophylaxis for portal hypertensive bleeding.
2. Viral oesophagitis
3. Bariatric surgery
4. Managing drug resistance in hepatitis B virus treatment
5. Indications for anti- Helicobacter pylori treatment and discuss different treatment regimens
6. Developmental anomalies of pancreas causing pancreatitis
7. Nutritional assessment in patient with malabsorption syndrome
8. Side-effects of Tacrolimus, interactions of other drugs with Tacrolimus
9. Parasites causing malabsorption
10. Radiation induced colitis
August 2012 :
I. Elaborate on : Pages Time Marks
1. Discuss the pathogenesis of sporadic as well as familial colorectal cancer. Briefly discuss the strategies to screen for colorectal cancer in relatives of the index patient.
2. How do you classify the causes of jaundice? Discuss the causes and management of isolated hyperbilirubinemia in detail.
II. Write notes on :
1. Pharmacotherapy of portal hypertensive bleeding.
2. Immunoglobulin A : importance in hepatic and GI systems.
3. Management of complications of obesity.
4. Management of drug resistant hepatitis B virus.
5. Tests to detect Helicobacter pylori infection.
6. Pancreas divisum : investigations, associated disorders, treatment.
7. Ursodeoxycholic acid : mechanisms of action and indications.
8. Side-effects of cyclosporine, interactions of other drugs with cyclosporine.
9. Strongyloidiasis : clinical manifestations and management.
10. Antibiotic associated colitis : investigations and treatment.
February 2013 :
I. Elaborate on :
1. Discuss the” esophageal motility in health and disease”.
2. Discuss the embryonic development of pancreas and congenital anomalies of pancreas
II Write notes on :
1) Discuss briefly the various steps evolved in the metabolism of vitamin B12
2) Mention the role played by Strongyloides stercoralis in various GI conditions
3) What is the blood supply of Pancreas?
4) Write short notes on “Gut preferred fuels”
5) Briefly mention criteria for diagnosing Night eating syndrome.
6) Elaborate on the role played by Kupffer cell in various liver disorders/ dysfunctions
7) How do you manage a patient suffering from Malt lymphoma?
8) Write briefly about the role played by Ghrelin
9) Discuss the importance of Immunohistochemistry in liver disease
10) Mention the diagnostic criteria and its implications in managing Barrett’s Metaplasia
August 2013 :
I. Elaborate on :
1. Describe the vascular supply of colon; Discuss the pathophysiology and causes of ischaemia of colon.
2. Describe the macroscopic and microscopic structure of pancreas. Discuss the pathogenesis of acute pancreatitis.
II. Write notes on :
1. Motilin.
2. Dendritic cells.
3. Tumour Suppressor Genes.
4. Terlipressin.
5. Zenker’s Diverticulum.
6. Gastric acid secretion.
7. Vitamin D.
8. Interferons.
9. Apoptosis.
10. Enteric microbiota.