Name of the University : The Tamilnadu Dr. M.G.R. Medical University
Degree : Doctor of Medicine (M.D.)
Branch : Branch XXI – IMMUNOHAEMATOLOGY AND BLOOD TRANSFUSION
Subject Code/Name : 2084/Recent Advances In Technology
Paper : IV
Document Type : Question Bank
Website : web.tnmgrmu.ac.in
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TNMGRMU Recent Advances In Technology Question Paper
M.D. DEGREE EXAMINATION
Sub. Code: 2084
Branch XXI – IMMUNOHAEMATOLOGY AND BLOOD TRANSFUSION
(For candidates admitted upto 2007-2008)
Paper IV – RECENT ADVANCES IN TECHNOLOGY
Q.P. Code : 202084
Time : Three hours
Maximum : 100 marks
Draw suitable diagram wherever necessary.
Related : TNMGR Endocrine Surgery-General M.Ch Question Bank : www.pdfquestion.in/4603.html
March 2009
Answer ALL questions. :
I. Essay questions: (2 x 20 = 40)
1. What is meant by the terms ‘window period’ and ‘residual risk’ in relation to microbiological screening of the blood supply? Critically evaluate the measures which may be taken to reduce the residual risk of transfusion transmissible viral infections in the developing world.
2. Hemovigilance.
II. Write short notes on : (10 x 6 = 60)
1. Pathogen inactivation of cellular blood products.
2. Stem cell plasticity.
3. Various adsorption columns used for therapeutic apheresis.
4. Use of microarray in transfusion medicine.
5. Stealth red blood cells.
6. Improved techniques in red cell serology.
7. Blood inventory management.
8. Yersinia enterocolitica.
9. Platelet gel.
10. Multicomponent collection.
February 2010
I. Essay questions: (2 x 20 = 40)
1. Describe the process of umbilical cord blood banking and transplantation.
2. Discuss the Blood Bank Information Systems.
II. Write short notes on : (10 x 6 = 60)
1. Bone marrow storage and processing.
2. Immunotherapy.
3. Plasma protein production by recombinant DNA technology.
4. Outpatient and home transfusions.
5. Peripheral blood stem cell collection.
6. Voluntary and mandatory standards in blood banking.
7. Basics of liability in blood bank.
8. Transcription mediated amplification technology.
9. Socio legal aspects related to blood banking.
10. HLA typing by DNA.
May 2011
Answer ALL questions in the same order. :
I. Elaborate on :
1. Critically evaluate the measures which may be taken to reduce the residual risk of transfusion transmitted viral infections in India.
2. Flow cytometry: basic principle and its application in transfusion medicine.
II. Write notes on :
1. CFU – Assay.
2. Discuss various products available for management of Hemophilia A.
3. Intravenous Immunoglobulin.
4. Molecular methods of ABO grouping.
5. Topical hemostatic agents.
6. Stealth RBCs.
7. Proteomics and its application in Transfusion Medicine.
8. Transcription Mediated Amplification.
9. Solvent Detergent (SD) treated fresh frozen plasma.
10. Donor Lymphocyte Transfusion.
April 2012
Answer ALL questions in the same order. :
I. Elaborate on :
1. Discuss about ABO incompatible Renal transplantation and the strategies to improve graft survival in the same.
2. Discuss about the various emerging infections threatening the safety of Blood supply in India.
II. Write notes on :
1. Describe Peripheral Blood stem cell collection and mention the indications for its use.
2. Discuss about public and private cord Blood Banking
3. Discuss the procedure and indications for therapeutic Apheresis.
4. Discuss about various methods for pathogen inactivation of Blood products.
5. Discuss about proteomics in Transfusion Medicine.
6. Dendritic cell therapy in malignancies of head and neck area.
7. Heamovigilance.
8. Discuss about Recombinant DNA technology.
9. Plasma Fractionation.
10. Critically evaluate the measures to be taken to reduce the residual risk of transfusion transmissible viral infections in our Country.
April 2013
Time: Three Hours
Maximum: 100 marks
I. Elaborate: (2×15=30)
1. Role of Nucleic Acid Testing in blood safety.
2. Indications of Therapeutic Plasma Exchange and the role of Immunoadsorption technology in Therapeutic Plasma Exchange.
II. Write Notes on: (10×7=70)
1. Platelet additive solutions
2. Universal RBC
3. Viral inactivation in Transfusion Medicine
4. Pathophysiology of Transfusion Related Acute Lung Injury ( TRALI )
5. Lectins in Transfusion Medicine
6. Gene therapy
7. Application of Micro-array technology in Transfusion Medicine
8. Pharmacological alternatives to transfusion
9. Tools for detection of bacterial contamination in platelets
10. Multi-component collection.