Name of the University : The Tamilnadu Dr. M.G.R. Medical University
Degree : Doctor of Medicine (M.D.)
Branch : Branch IV – MICROBIOLOGY
Subject Code/Name : 2017/Mycology And Applied Microbiology And Recent Advances
Paper : IV
Document Type : Question Bank
Website : web.tnmgrmu.ac.in
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TN MGRMU Applied Microbiology Question Paper
March 2009 :
Sub. Code: 2017
M.D. DEGREE EXAMINATION
Branch IV : MICROBIOLOGY
Related : TNMGRMU Immunopathology, Haematology Principles & Applications to Technological Advances in Laboratory Services MD Question Bank : www.pdfquestion.in/4278.html
(Common to all candidates)
Paper IV : MYCOLOGY AND APPLIED MICROBIOLOGY AND RECENT ADVANCES
Q.P. Code : 202017
Time : Three hours Maximum : 100 marks
Draw suitable diagram wherever necessary.
Answer ALL questions.
I. Essay questions : (2 x 20 = 40)
1. Define quality assurance. Discuss in detail quality control programmes for clinical microbiology laboratory.
2. Discuss antifungal susceptibility testing methods for candida species with their merits and demerits.
II. Write short notes on : (10 x 6 = 60)
1. Mycetoma.
2. DNA microarrays and its application.
3. Disc approximation ‘D’ test for staphylococci.
4. Histoplasmosis.
5. Fungal stains.
6. Surface mycoses.
7. Flow cytometry.
8. Immuno chromatography.
9. Amp ‘C’ – ß lactamases in GNB.
10. Penicillium marneffi infection.
September 2009
I. Essay questions : (2 x 20 = 40)
1. Discuss the recombinant genetic engineering techniques and its applications.
2. National Aids control organization policy of diagnosis of HIV infection. Add a note on HIV vaccines.
II. Write short notes on : (10 x 6 = 60)
1. Gene cloning
2. Biological weapons
3. Typing methods in bacteria
4. Non gonococcal urethritis
5. Salmonella food poisoning
6. ESBL detection in the laboratory
7. Newer fluroquinolones
8. Revised national tuberculosis control programme
9. Bacteriology of milk
10. Cytokines
March 2010
I. Essay questions : (2 x 20 = 40)
1. Discuss important cytokines and their selected biologic effects.
2. Laboratory aids in the selection of antimicrobial therapy.
II. Write short notes on : (10 x 6 = 60)
1. Prions.
2. B.O.D. incubator.
3. Superficial mycoses.
4. Exospore.
5. Fc Farland tubes.
6. Jumping genes.
7. Opportunistic parasitic infections in AIDS.
8. Antiviral vaccines for HIV/AIDS.
9. Bioterrorism.
10. Biomedical waste disposal
Sub. Code: 2017
I. Essay questions : (2 X 20 = 40)
1. Discuss in detail about Antibiotic sensitivity testing.
2. Describe the Antigenic variations in orthomyxoviruses and their epidemiological importance.
II. Write short notes on : (10 X 6 = 60)
1. Morphological classification of fungi.
2. Mycotoxins.
3. Automation in Microbiology.
4. Opportunistic fungi.
5. Blood culture.
6. Specimen collection in mycetoma.
7. Bird Flu.
8. Pigment producing fungi.
9. Biomedical waste disposal.
10. Superficial mycosis.
May 2011
I. Essay: (Max.) (Max.) (Max.)
1. Define Dimorphic fungi. Enumerate them. Describe the morphology, pathogenesis and lab diagnosis of Histoplasmosis causative organism.
2. List the Zoonotic diseases. Name the prevalent bacterial zoonotic diseases in India. Describe the morphology, cultural characteristics antigenic structure and lab diagnosis of Brucellosis.
II. Short Questions :
1. Dermatophytes.
2. Madura mycosis.
3. Mycetism and Mycotoxicosis.
4. Universal immunization programme.
5. Prevention of hospital acquired infection.
6. Microbial pathogenicity.
7. Recent advances in detection of M.tuberculosis.
8. Recent immunological methods available for detection of antigen.
III. Reasoning Out :
1. Biomedical waste management is mandatory in all hospitals, labs and healthcare delivery places.
2. Phage typing is used in epidemiological typing.
3 Though one or two doses of OPV has produced 90-100% seroconversion in advanced countries but not so in developing countries in the tropics.
4. Flow cytometry is technologically sophisticated approach than immuno fluorescence.
IV. Very Short Answers :
1. Types of fungal spores.
2. Post exposure prophylaxis of HIV.
3. Types of PCR.
4. Standards to be maintained in the levels of airborne bacteria level in hospital air.
5. Latent infection.
6. HIV protein types blotted on Nitrocellulose paper.
7. Cold agglutination test.
8. Biological false positive reactions.
9. Weakly acid fast onganisms.
10. Thioglycollate medium.
April 2012
I. Essay:
1. Enumerate the causative agents of mycetoma foot. Describe the pathogenesis and laboratory diagnosis of Eumycotic mycetoma.
2. What are Hospital acquired Infections? Write in detail about laboratory diagnosis and control of hospital acquired infections.
II. Short Questions :
1. List Mycotoxins and discuss the pathogenesis of any one mycotoxin.
2. Discuss the causative agent and pathogenic lesion due to Lobomycoses.
3. Describe the causative agent and laboratory diagnosis of Piedra.
4. Discuss the composition and uses of Sabourauds Dextrose Agar.
5. Enumerate the Normal flora of skin and its benefits.
6. Describe the principle and procedure of Disk Diffusion method to study antibiotic sensitivity pattern.
7. List Recombinant vaccines, describe the production of recombinant Hepatitis B Vaccine.
8. What is Bio-film? What are the methods to detect it in vitro?
III. Reasoning Out :
1. Demonstration of Fungus in nails is difficult and is possible only after using 10% Potassium hydroxide. Explain.
2. In Mycetoma foot why the sinuses discharge granules.
3. Explain why Dihptheria and tetanus toxoids are given with Bordetella pertusis vaccine.
4. More than 105 CFU/ml denotes significant bacteriuria. Explain.
IV. Very Short Answers :
1. Give two examples for anthropophilic fungus.
2. Name the causative agent of white piedra.
3. List four fungus causing Systemic mycoses.
4. Draw the macroconidia of Histoplasma capsulatum.
5. Name four pathogenic species of Candida.
6. Give the CFU/ml corresponding to 0.5 Mc Farland standard.
7. List two examples for passive immunization.
8. Enumerate two characters of endotoxins.
9. Name two methods used for Air sampling.
10. Name the gene responsible for methicillin resistance in MRSA.