Name of the University : The Tamilnadu Dr. M.G.R. Medical University
Degree : Doctor of Medicine (M.D.)
Branch : Branch III – Pathology
Subject Code/Name : 2013/Immunopathology, Haematology Principles And Applications To Technological Advances In Laboratory Services
Paper : IV
Document Type : Question Bank
Website : web.tnmgrmu.ac.in
Download Model/Sample Question Paper :
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TNMGRMU Haematology & Applications Question Paper
[KT 116] Sub. Code: 2013
M.D. DEGREE EXAMINATION
Branch III – Pathology
Paper IV – Immunopathology, Haematology Principles And Applications To Technological Advances In Laboratory Services
(Common to all candidates)
Related : Tamilnadu Dr. M.G.R. Medical University Systemic Pharmacology Including Recent Advances MD Question Bank : www.pdfquestion.in/4284.html
September 2008
Q.P. Code : 202013
Time : Three hours
Maximum : 100 marks
Draw suitable diagram wherever necessary. :
Answer ALL questions. :
I. Essay questions : (2 X 20 = 40)
1. Classify anemias. Discuss the etiopathogenesis, morphology and lab diagnosis of pernicious anemia.
2. Discuss the available immune markers in diagnostic pathology. Mention the recent advances in identification of tumors by immuno-histochemistry.
II. Write short notes on : (10 X 6 = 60)
1. Utility and accuracy of zeta sedimentation.
2. Tropical sprue.
3. Recent advances in stem cell therapy.
4. Discuss pulmonary cytopathology — routine and ancillary treatment.
5. Diseases of red cell membrane.
6. Complications of plasmacytoma.
7. Automation in urine analysis.
8. Von-willebrand’s disease.
9. Recent advances in organ transplantation protocols.
10. Antibody – dependent cell mediated cytotoxicity (ADCC).
March 2009
I. Essay questions : (2 x 20 = 40)
1. Define disseminated intravascular coagulation. Describe the
etiopathogenesis and laboratory diagnosis.
2. Discuss prognostic indices of breast carcinoma.
II. Write short notes on : (10 x 6 = 60)
1. Describe the role of serum lipids in health and disease.
2. Discuss molecular basis and diagnosis of thalassemia.
3. Discuss role of automation in clinical pathology.
4. Recent concepts in papillary carcinoma of thyroid.
5. Micro satellite instability.
6. Congenital dyserythropoitic anemias.
7. Laboratory diagnosis of acute leukemias.
8. Describe principles and applications of flow cytometry.
9. Role of immunity in Hodgkins disease.
10. FNAC of thyroid lesions.
September 2009
I. Essay questions : (2 x 20 = 40)
1. Classify haemolytic anaemias. Discuss the etiopathogenesis, clinical features and laboratory findings in immune haemolytic anaemia.
2. Discuss the role of immunohistochemistry and molecular biology in the classification of lymphomas and leukemia.
II. Write short notes on : (10 x 6 = 60)
1. Atypical chronic myeloid leukemia
2. Aggregometer
3. Automation in ESR
4. Liquid based cytology preparation
5. Thrombasthenia
6. Tests for Bence Jones protein
7. Fanconi’s anaemia
8. LAP test
9. Downy cell
10. Pleocytosis
March 2010
I. Essay questions : (2 x 20 = 40)
1. How do you investigate myelodysplastic syndrome?
2. Lymphoma – update.
II. Write short notes on : (10 x 6 = 60)
1. Banking of haematopoetic stem cell.
2. Stromal reactions of bone marrow.
3. Platelet therapy and apheresis.
4. Minimal residual disease in leukemia.
5. Discuss organization and legal concerns of blood banking.
6. Haemoglobinopathies in India.
7. ß – Thalassemia – molecular biology and laboratory diagnosis.
8. Acute prolymphocytic leukemia.
9. Stains used in vaginal cytology.
10. Discuss creatinine clearance tests.
September 2010
Q.P. Code : 202013
Time : Three hours
Maximum : 100 marks
Draw suitable diagram wherever necessary.
Answer ALL questions.
I. Essay questions : (2 X 20 = 40)
1. What are blood components? Describe the preparation, storage and uses of blood components.
2. Classify anemias. Discuss the etiopathogenesis, clinical features and laboratory findings in Aplastic anemia.
II. Write short notes on : (10 X 6 = 60)
1. Glycosylated Haemoglobin.
2. Electrophoresis.
3. Interpretation of synovial biopsies.
4. Importance of calibration verification in clinical laboratory.
5. Myeloproliferative diseases.
6. Refractory anemias.
7. Idiopathic thrombocytopenia.
8. DIVC.
9. Paps smear.
10. Atypical chronic myeloid leukemia.
May 2011
[KY 116] Sub. Code: 2013
M.D. Degree Examination
Branch Iii – Pathology
Immunopathology, Haematology, Principles And
Applications To Technological Advances In Laboratory Services
Q.P. Code : 202013
Time : 3 hours
Maximum : 100 marks (180 Min)
Answer ALL questions in the same order.
I. Essay:
1. Discuss the pathogenesis, morphology and complications of sickle cell disease. 6 15 10
2. Digital photography in histopathology. 6 15 10
II. Short Questions:
1. S 100. 3 8 5
2. Latest classification of myeloid neoplasms. 3 8 5
3. Pathology of bonenarrow failure. 3 8 5
4. Von Willibrand disease. 3 8 5
5. Molecular markers of early cervical neoplasia. 3 8 5
6. Mantle cell lymphoma. 3 8 5
7. Hairy cell leukemia. 3 8 5
8. Tissue array. 3 8 5
III. Reasoning Out:
1. 62/F presented with mild weakness. On examination she hadcervical and supraclavicular lymphadenopathy. Total count was 185000/µL, Peripheral smear was done. 4 10 5 Describe the molecular pathogenesis, morphology and prognosis for this case.
2. 36/F presented with fatigue and weakness. Peripheral smear was taken. Discuss the morphology and etiology of the case. 4 10 5
3. 40/F presented with fever with rigor and mild hepatosplenomegaly. Peripheral smear was done for diagnosis. Discuss in detail the Peripheral smear picture. 4 10 5
4. 42/F admitted with fever, night sweat, weight loss, painless cervical lymphadenopathy. Lymph node biopsy was done. CD15 and CD30 positive. Describe the morphology and molecular genetics of this disease. 4 10 5
IV. Very Short Answers :
1. Dorfman Chanarin syndrome. 1 4 2
2. P blood group. 1 4 2
3. B cell associate antigens detected by monoclonal antibodies. 1 4 2
4. Letterer-Siwe disease. 1 4 2
5. Pure red cell aplasia. 1 4 2
6. Secondary polycythemia. 1 4 2
7. Absolute eosinopil count. 1 4 2
8. Clot retraction. 1 4 2
9. Bleeding time. 1 4 2
10. Dutcher bodies. 1 4 2