Name of the University : The Tamilnadu Dr. M.G.R. Medical University
Degree : M.Pharm DEGREE EXAMINATION
BRANCH VIII : PHARMACEUTICAL BIOTECHNOLOGY
Subject Code/Name : 2874/Herbal Drug Development And Standardisation
Year : I
Paper : III
Document Type : Question Bank
Website : web.tnmgrmu.ac.in
Download Model/Sample Question Paper :
2011-2014 : https://www.pdfquestion.in/uploads/web.tnmgrmu.ac.in/PHARMACY/3877-262874KX.pdf
Herbal Drug Development & Standardisation :
March 2009 :
[KU 338] Sub. Code: 2874
M.PHARM. DEGREE EXAMINATION :
(Regulations 2006)
Related : TNMGRMU Bioprocess Technology M.Pharm Question Bank : www.pdfquestion.in/3875.html
Candidates admitted from 2006-2007 onwards
Paper III : HERBAL DRUG DEVELOPMENT AND STANDARDISATION
Q.P. Code : 262874
Time : Three hours
Maximum : 100 marks
Answer All questions :
I. Essay Questions : (3 x 20 = 60)
1. Describe the different methods of extraction and add a note on their merits and demerits.
2. Discuss the various dosage forms in herbal drugs. Explain how you will evaluate them.
3. Discuss the different methods for isolation and estimation of Alicin from garlic.
II. Write Short Notes : (8 x 5 = 40)
1. Authentification of herbs.
2. Methods of drying.
3. Super critical fluid extraction.
4. Toxicity studies of herbal extracts.
5. Stability studies of herbal formulations.
6. Good agricultural practices.
7. Incorporating herbal extracts on hair care preparations.
8. Good collection practices of plant materials.
September 2009 :
I. Essay Questions : (3 x 20 = 60)
1. a) Write an essay on the protocol for fractionation of a root drug for isolation of various secondary metabolites.
b) Discuss the principle, merits and demerits of supercritical fluid extraction.
2. a) Discuss the principles of development of fingerprint profile of standardized herbal extracts.
b) Discuss the OECD guidelines for determination of acute toxicity of plant drugs.
3. a) Explain the principle behind the isolation and estimation of catechine from green tea.
b) Discuss the isolation and estimation of piperine by HPLC.
II. Write Short Notes : (8 x 5 = 40)
1. Documentation requirements in quality control of botanicals.
2. WHO definitions for herbs, herbal materials, herbal preparations, finished herbal products. Therapeutic activity and active ingredients.
3. Herbal shampoos.
4. Isolation of bitter lactones from andrographis.
5. Recovery of solvents from extracts.
6. Merits and demerits of artificial drying.
7. Disc diffusion and serial dilution.
8. Storage requirements for crude drugs.
March 2010 :
I. Essay Questions : (3 x 20 = 60)
1. a) Describe the general methods of preparation of plant extracts and their merits and demerits.
b) Write an essay on the stability studies of herbal formulations.
2. a) Discuss the physicochemical properties of Forskolin and describe its isolation for the source herb.
b) Outline good agricultural practices with respect to yield enhancement in medicinal plants.
3. a) Enumerate commercially importance herbs of cosmetic significance. Add a note on the methods of their incorporation in cosmetic formulations.
b) Discuss the quality control protocols for the evaluation of herbal liquids.
II. Write Short Notes : (8 x 5 = 40)
1. Procurement and authentications of herbs.
2. Microscopic evaluation of crude drugs.
3. Special analysis of drug extracts.
4. Methods of evaluation of cardiotoxicity.
5. Isolation of bacosides from bacopa.
6. Regulatory requirements for the export of herbal drugs.
7. Quantitative analysis of herbals preparations by HPTLC.
8. Precautions to be taken in the collection of plant materials.
September 2010 :
I. Essay Questions : (3 x 20 = 60)
1. a) Briefly discuss on GMP for the production of quality botanicals.
b) Define extraction. Highlight various methods of extraction with merits and demerits.
2. a) Describe the methods involved in standardization of herbal raw materials.
b) Add a note on L-dopa from Mucuna pruriens.
3. a) Write the methods of purification and solvents utilizing the New Modern methods of technique in industries.
b) Describe the OECD 423 guidelines for determination of acute toxicity study of Herbal drugs.
II. Write Short Notes : (8 x 5 = 40)
1. Standardization of Green Tea.
2. Merits and demerits of methods of Drying.
3. Toxicity studies of herbal extracts.
4. Stability studies of herbal formulation.
5. Preparation of skin care cream and lotion.
6. Regulatory provisions relating to manufacture of cosmetics.
7. Skin sensitivity testing.
8. Hair care preparations.
Pharmaceutical Aspects Of Microbial And Cellular Biology :
I. Essay Questions : (6 x 10 = 60)
1. Detail about preparation and purification of DiphtheriaToxoid.
2. Classify immunity and explain.
3. Production of interferon’s.
4. Outline about growth curve of bacteria.
5. Write detail about secondary metabolites and its application.
6. Give an account of Humoral and cellular immunity.
II. Write Short Notes : (8 x 5 = 40)
1. Differentiate prokaryotic and eucaryotic microorganism.
2. Function of MHC.
3. Application of cell culture in pharmaceutical industry.
4. Mathematical explanation of bacterial growth.
5. Conjugation.
6. Structure of prokaryotic micro organism.
7. Synthesis of protein.
8. Classify bacteria depend on temperature.