Name of the University : The Tamilnadu Dr. M.G.R. Medical University
Degree : M.Pharm DEGREE EXAMINATION
Subject Code/Name : 2901/Modern Pharmaceutical Analytical Techniques
Year : I
Paper : I
Document Type : Question Bank
Website : web.tnmgrmu.ac.in
Download Model/Sample Question Paper :
2011-2014 : https://www.pdfquestion.in/uploads/web.tnmgrmu.ac.in/PHYSIOTHERAPY/3848-262901KY.pdf
Modern Pharmaceutical Analytical Techniques :
MAY 2011 :
[KY 340]
Sub. Code: 2901
M.PHARM. DEGREE EXAMINATION :
(Regulations 2010)
Related : TNMGRMU Advanced Medicinal Chemistry M.Pharm Question Bank : www.pdfquestion.in/3854.html
(For candidates admitted from 2010-2011 onwards)
PAPER I : Modern Pharmaceutical Analytical Techniques
(Common to all Branches)
Q.P. Code : 262901
Time : Three hours
Maximum : 100 marks
Answer All questions :
I. Essay Questions: (6 x 10 = 60)
1. a) Briefly explain the proton exchange reaction in NMR spectroscopy. (5)
b) Outline the salient features of NMR spectroscopy which are used in structural elucidation. (5)
2. Write a note on
a) Quadrupole mass spectrometer.
b) Theory behind mass spectroscopy.
3. Write the principle and working of ion exchange chromatography.
4. Explain briefly:
a) IR detectors (5)
b) Instrumentation of spectroflourimeter (5)
5. Explain briefly about fundamental vibration.
6. Discuss the various techniques employed in the assay of multicomponent mixture
by UV spectrophotometer.
II. Write Short Notes on: (8 x 5 = 40)
1. What is theoretical plate and give its significance? How is it calculated?
2. Briefly explain the principle and application of flame emission spectrophotometer.
3. Write the criteria for fluorescence and its Pharmaceutical application.
4. Predict the signal position (d value) in the NMR spectra of
1) Benzyl alcohol 2) Ethyl benzene
5. Give the application of CD and ORD in Pharmacy.
6. The proposed structure for an organic compound shows m/e peak at 46, 31 and 29.confirm the structure by fragmentation mode.
7. Give the significance of Regression analysis and correlation coefficient.
8. Elution technique employed in HPTLC.
October 2011 :
Answer ALL questions in the same order. :
I. Elaborate on : Pages Time Marks
1. (a) Explain the general fragmentation patterns for the interpretation of organic compounds in Mass Spectrometry.
(b) Give the Mass interpretation patterns for the following organic compounds. (i) Benzyl alcohol (ii) 2 – Hexanone (iii) Benzaldehyde (iv) Benzamide.
2. (a) Write theory of fluorescence with neat diagram.
(b) Explain the relationship between
(i) Chemical structure and Fluorescent intensity
(ii) pH and Fluorescent intensity.
II. Write notes on :
1. Give the significance of students ‘t’ test and F – test.
2. Write the principle and methods involved in Radio Immunoassay.
3. Briefly explain about Gel Electrophoresis.
4. Compare and contrast Normal Phase Chromatography and Reverse Phase Chromatography.
5. How will you identify and determine the separated components from the mixture by Thin Layer Chromatography.
6. Write a brief account on Differential Scanning Calorimetry.
7. Define ORD and Octant rule. Write their applications with suitable examples.
8. How will you produce X – rays? Explain with neat diagram.
9. Explain the fundamental vibrations of the molecules in IR Spectrophotometry.
10. (a) Relationship between concentration and Fluorescence intensity. (b) Define Quenching. Write the types of Quenching.
MAY 2012 :
Answer ALL questions in the same order. :
I. Elaborate on:
1. a) Explain the theory of Electronic Spectroscopy and the different types of electronic transitions encountered in UV Spectroscopy.
b) Explain the terms Chromophore and Auxochromes with examples.
c) Discuss the Woodward Fieser Rules for calculating Absorption maximum in dienes.
2. a) Explain the different relaxation Process in NMR Spectroscopy by which a nucleus in an upper transition state returns to the lower state.
b) Describe the instrumentation of an NMR Spectrophotometer.
c) Draw a neat sketch of the NMR Spectrum you expect to get for 1, 1- dibromoethane
II. Write notes on :
1. Describe the construction and working of the following:
a) Hollow cathode lamp used as light source in Atomic Absorption Spectroscopy b) Photomultiplier Tube.
2. Draw a schematic diagram of a Gas Chromatograph set up and briefly explain the working.
3. Discuss the important features of the parent ion peak in Mass Spectrometry.
4. Discus the important factors affecting Differential Thermal Analysis.
5. Write a short note on the principle underlying Ion Exchange Chromatography.
6. State Bragg’s Law. Explain the X-Ray Powder Diffraction method.
7. Explain Circular Dichroism and its relationship to Optical Rotatory Dispersion.
8. Explain the different Sampling Techniques employed in Infrared Spectrophotometry.
9. a)State the properties of Coefficient of Correlation.
b) How will you interpret a value of r=0?
10. Discuss briefly the essential components of a research report.