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Name of the University : The Tamilnadu Dr. M.G.R. Medical University
Degree : D.Pharm
Subject Code/Name : 3823/Biopharmaceutics And Pharmacokinetics
Year : IV
Paper : V
Document Type : Question Bank
Website : tnmgrmu.ac.in

Download Model/Sample Question Paper :
2011-2014 : https://www.pdfquestion.in/uploads/web.tnmgrmu.ac.in/PHARMACY/3816-383823KX.pdf

TNMGRMU Biopharmaceutics & Pharmacokinetics  Questions

September 2009 :
[KV 823] Sub. Code: 3823
DOCTOR OF PHARMACY (PHARM. D / POST BACCALAUREATE)
DEGREE EXAMINATION

Related : TNMGRMU Pharmacotherapeutics–III D.Pharm Question Bank : www.pdfquestion.in/3815.html

(Regulations 2008 – 2009)
(Candidates admitted from 2008-2009 onwards)
Paper V : BIOPHARMACEUTICS AND PHARMACOKINETICS
Q.P. Code : 383823
Time : Three hours
Maximum : 70 marks
Answer All questions :
I. Essay Questions : (2 x 20 = 40)
1. Elaborate on the pharmacokinetic model and equations in one compartment open model I.V. bolus.
2. a) Define bio-equivalence. List the various methods involved in the determination of bio-equivalence.
b) Elaborate on any one delivery system for estimation of bioequivalence.

II. Write Short Notes : (6 x 5 = 30)
1. Physiological barrier to drug distribution.
2. Causes of non-linearity with example.
3. Mean residence time.
4. Limitations of multi compartmental analysis.
5. Renal impairment and creatinin clearance.
6. A drug has to be administered as a continuous I.V. infusion so as to reach a
study state concentration of 0.5mcg/ml. What should be the infusion rate if
it is following the one compartment model? (T½=8 hr and Va=13L)

April 2013

I. Elaborate on : (2×20=40)
1. Discuss the principles that governs the renal excretion of drugs?
2. Discuss in detail the physiochemical factors affecting drug absorption?
II. Write notes on : (10×6=60)
1. Write a note on drug –drug interactions in Gastro intestinaltract?
2. Discuss the importance of salivary excretion of drugs?
3. Derive the equation for one compartment open model intravenous infusion?
4. Write the procedure involved in the determination of elimination rate constant using urinary excretion data?
5. Derive the equation for two compartment open model extravascular administration?
6. Write a note on Michaelis menten equation?
7. Discuss in detail regulatory requirements for bioavailability study?
8. The dose of amoxicillin capsule was 500 mg and theAUC was 50.9 mcghr/L. The dose of suspension was 500 mg and the AUC is 61.93 mcghr/L . Calculate the relative bioavailability of capsule to the oral suspension
9. An ophthalmic solution of mydriatic drug at 5 mg/ml exhibits first order degradation with rate of 0.0005 /day. How much drug will remain after 120 days?
10. Differentiate passive diffusion and active transport?

October 2013

I. Elaborate on: (2 x 20 = 40)
1. Define drug absorption. Discuss the various factors influencing GI absorption of a drug.
2. Discuss the one compartment open model intra venous administration.
II. Write notes on: (10 x 3 = 30)
1. Explain in brief about Michaelis menten equation
2. Explain the Mean residence time
3. Apparent volume of distribution
4. Methods to enhance the bioavailability through enhancement of drug solubility
5. How will you find out Km and Vmax from steady state concentration?
6. What are the major parameters studied in the urinary excretion data?
7. What are the factors affecting drug dissolution and dissolution rate?
8. Write the concept and types of clearance
9. The drug has an elimination half life of 6 hrs and follows first order kinetics.
If a single dose of 500 mg is given to an adult male (68 kg) patient by I.V bolus injection, what will be the percentage of dose lost in 24 hrs?
10. Statistical moment theory.

April 2014

I. Elaborate on : (2×20=40)
1. Drug elimination.
2. A 70 kg patient is to be a given a drug by i.v. infusion. The drug has a half life of 22 hours, apparent volume of distribution 15.7 litres and desired steady state plasma concentration is 0.0002 mcg/ml. Assuming one compartment kinetics calculate; time to reach 90% steady state concentration, infusion rate to achieve desired steady state concentration, loading dose to attain steady state rapidly and concentration of drug in plasma after 48 hours from the start of infusion.
II. Write notes on : (10×3=30)
1. Enlist physiological barriers for distribution
2. Statistical interpretation of bioequivalence data
3. Endocytosis
4. Tissue localization
5. Plasma level time curve
6. Advantages of Catenary model
7. Lineweaver-Burke Plot
8. Persistance factor and loss factor
9. Approaches for dosage regimen
10. Dissolution apparatus I