Name of the University : The Tamilnadu Dr. M.G.R. Medical University
Degree : B.Pharm
Subject Code/Name : 4240/Hospital & Clinical Pharmacy
Year : III
Paper : V
Document Type : Question Bank
Website : web.tnmgrmu.ac.in
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TN MGRMU Clinical Pharmacy Question Paper
[KY 749] Sub. Code : 4240
Related / Similar Question Paper : TNMGRMU B.Pharm Pharmacology-I Question Bank
THIRD B.PHARM. DEGREE EXAMINATION. :
(Regulation 2004)
(For Candidates admitted from 2004 – 2005 onwards)
February 2011
Paper V : HOSPITAL AND CLINICAL PHARMACY
Q.P. Code : 564240
Time : Three hours
Maximum : 75 marks
I. Essay Questions :
Answer any TWO questions. (2 x 20 = 40)
1. (a) Dispensing of drugs to in-patients , types of drug distribution system, charging policy and labeling.
(b) Discuss the scope of clinical pharmacy in India.
2. (a) Role of Hospital Pharmacist in Educational and Training Programme.
(b) Concept of Medication history interviews, and patient medication counselling.
3. (a) Explain in detail about ADR: its classification, excessive pharmacological effects, secondary pharmacological effects and pharmacokinetic drug Interactions.
(b) Write notes on:
(i) Radio active half-life
(ii) Units of Radio-activity
(iii) Radiation Hazards, their prevention and specifications for radio active laboratory.
II. Write Short Notes :
Answer any FIVE questions. (5 x 5 = 25)
1. Responsibilities of Hospital Pharmacist.
2. Dispensing of drugs to Ambulatory Patients.
3. Preparation of Radio-Isotopes in laboratory using Radiation Dosimetry and Radio-Isotope generators.
4. Methods of Detecting Adverse Drug Effects.
5. Role of Pharmacist in public awareness and continuing education programmes.
6. Dispensing of Controlled Drugs.
7. Packing of Materials Prior to Sterilization.
III. Short Answers:
Answer any FIVE questions. (5 x 2 = 10)
1. Ward Pharmacy.
2. Effect of Antidiabetics with corticosteriods.
3. Controlled Drugs
4. Hospital Formulary
5. Idiosyncrasy
6. Nuclear Pharmacy
7. Pharmacy and Therapeutic Committee.
August 2011
I. Essay questions: (2 x 20 = 40)
1. Discuss in detail the preparation of radioisotopes and specifications for radioactive laboratory?
2. Explain in detail the preparation of Hospital formulary?
II. Write short notes on: (8 x 5 = 40)
1. Discuss the functions of Pharmacy and Therapeutic committee.
2. Write the procedure involved in dispensing of controlled drugs.
3. Mention the packing materials used prior to sterilization.
4. Explain drug – drug interaction with examples.
5. Write the methods for collecting drug information.
6. Write about the dosage individualization in patients.
7. Write a note on Prescription filling?
8. Discuss the steps in counseling.
III. Short Answer Questions: (10 x 2 = 20)
1. Types of purchase.
2. Important contents of Hospital formulary.
3. Examples for sterilization equipments.
4. Define radioactive half life.
5. Record linkage studies.
6. Define ward Pharmacy
7. Importance of Master formula card
8. Two disease treatment schedule
9. Types of charging policy
10. Continuing education programme for pharmacist
Medicinal Chemistry – III (Theory)
Syllabus
UNIT – I :
Antibiotics Historical background, Nomenclature, Stereochemistry, Structure activity relationship, Chemical degradation classification and important products of the following classes.
β-Lactam antibiotics: Penicillin, Cepholosporins, β- Lactamase inhibitors, Monobactams Aminoglycosides: Streptomycin, Neomycin, Kanamycin Tetracyclines: Tetracycline,Oxytetracycline, Chlortetracycline, Minocycline, Doxycycline
UNIT – II :
Antibiotics Historical background, Nomenclature, Stereochemistry, Structure activity relationship, Chemical degradation classification and important products of the following classes.
Macrolide: Erythromycin Clarithromycin, Azithromycin. Miscellaneous: Chloramphenicol*, Clindamycin. Prodrugs: Basic concepts and application of prodrugs design. Antimalarials: Etiology of malaria.
Quinolines: SAR, Quinine sulphate, Chloroquine*, Amodiaquine, Primaquine phosphate, Pamaquine*, Quinacrine hydrochloride, Mefloquine. Biguanides and dihydro triazines: Cycloguanil pamoate, Proguanil. Miscellaneous: Pyrimethamine, Artesunete, Artemether, Atovoquone.
UNIT – III :
Anti-tubercular Agents Synthetic anti tubercular agents: Isoniozid*, Ethionamide, Ethambutol, Pyrazinamide, Para amino salicylic acid.* Anti tubercular antibiotics: Rifampicin, Rifabutin, Cycloserine Streptomycine, Capreomycin sulphate.
Urinary tract anti-infective agents Quinolones: SAR of quinolones, Nalidixic Acid,Norfloxacin, Enoxacin, Ciprofloxacin*, Ofloxacin, Lomefloxacin, Sparfloxacin, Gatifloxacin, Moxifloxacin Miscellaneous: Furazolidine, Nitrofurantoin*, Methanamine.
Antiviral agents: Amantadine hydrochloride, Rimantadine hydrochloride, Idoxuridine trifluoride, Acyclovir*, Gancyclovir, Zidovudine, Didanosine, Zalcitabine, Lamivudine, Loviride, Delavirding, Ribavirin, Saquinavir, Indinavir, Ritonavir.
UNIT – IV :
Antifungal agents : Antifungal antibiotics: Amphotericin-B, Nystatin, Natamycin, Griseofulvin. Synthetic Antifungal agents: Clotrimazole, Econazole, Butoconazole, Oxiconazole Tioconozole, Miconazole*, Ketoconazole, Terconazole, Itraconazole, Fluconazole, Naftifine hydrochloride, Tolnaftate*.
Anti-protozoal Agents: Metronidazole*, Tinidazole, Ornidazole, Diloxanide, Iodoquinol, Pentamidine Isethionate, Atovaquone, Eflornithine. Anthelmintics: Diethylcarbamazine citrate*, Thiabendazole, Mebendazole*, Albendazole, Niclosamide, Oxamniquine, Praziquantal, Ivermectin.
Sulphonamides and Sulfones Historical development, chemistry, classification and SAR of Sulfonamides: Sulphamethizole, Sulfisoxazole, Sulphamethizine, Sulfacetamide*, Sulphapyridine, Sulfamethoxaole*, Sulphadiazine, Mefenide acetate, Sulfasalazine. Folate reductase inhibitors: Trimethoprim*, Cotrimoxazole. Sulfones: Dapsone*.
UNIT – V :
Introduction to Drug Design Various approaches used in drug design. Physicochemical parameters used in quantitative structure activity relationship (QSAR) such as partition coefficient, Hammet’s electronic parameter, Tafts steric parameter and Hansch analysis.
Pharmacophore modeling and docking techniques. Combinatorial Chemistry: Concept and applications chemistry: solid phase and solution phase synthesis of combinatorial