Name of the University : The Tamilnadu Dr. M.G.R. Medical University
Degree : B.Pharm
Subject Code/Name : 4257/Pharmaceutical Analysis And Physical Chemistry
Year : II
Paper : II
Document Type : Question Bank
Website : web.tnmgrmu.ac.in
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TN MGRMU Pharmaceutical Analysis Question Paper
Sub. Code: 4257
SECOND YEAR B.PHARM. EXAM
Related / Similar Question Bank :
TNMGRMU B.Pharm Physical Pharmaceutics Question Bank
Paper II – PHARMACEUTICAL ANALYSIS AND PHYSICAL CHEMISTRY
Q.P. Code : 564257
Time : Three hours
Maximum: 100 Marks
(180 Min)
AUGUST 2012
Answer ALL questions in the same order. :
Answer Section A and B in SEPARATE Answer Book. :
SECTION A :
(PHARMACEUTICAL ANALYSIS)
I. Elaborate on:
1. a) Explain in detail about oxygen flask combustion method?
b) Masking and de-masking agents in complexometric titrations.
II. Write notes on:
1. How do you determine the acid value?
2. Write notes on dead stop end point?
3. Write the mechanism of buffer and its applications?
4. What is Gasometry? Give the procedure for the assay of oxygen?
III. Short Answers:
1. Define iodometry?
2. Give the example of acid-base indicators?
3. What is plane polarized light? How it is achieved?
4. Define chelating agents?
5. What is a real and ideal solution?
SECTION – B :
(PHYSICAL CHEMISTRY)
IV. Elaborate on:
2. Define and explain the various types of colligative properties. Write the methods used for determining the elevation of boiling point? 19 33 20
V. Write notes on:
1. Explain Debye-Huckel’s theory?
2. Explain Phase rule and the terms phase, component and degrees offreedom?
3. What is plane polarized light? How it is achieved?
4. Explain Hess law of constant heat of summation?
VI. Short Answers:
1. Define partition co-efficient?
2. State second law of thermodynamics?
3. What is Nernst distribution?
4. Define order of reaction?
5. What is adsorption?
FEBRUARY 2013
(180 Min)
Answer Section A and B in SEPARATE Answer Book. :
SECTION – A :
(PHARMACEUTICAL ANALYSIS)
I. Elaborate on: (2×10=20 marks)
1. a) Explain the different types of complexometric titrations by using various titrants with suitable examples.
b) Masking and demasking agents in complexometric titrations.
II. Write notes on: (4×5=20 marks)
1. Write the importance of quality control of drugs.
2. Write a note on kjeldhal method of nitrogen estimation.
3. Define co-precipitation and post precipitation. Give notes on various step involved in Gravimetric analysis.
4. Give the Henderson- Hasselbalch equation.
III. Short Answers: (5×2=10 marks)
1. Werner’s co-ordination number.
2. Define common ion effect.
3. Give some examples of oxidizing and reducing agents.
4. Define Redox potential.
5. Define Accuracy.
SECTION – B :
(PHYSICAL CHEMISTRY)
I. Elaborate on: (2×10=20 marks)
1. a) Explain the Second law of Thermodynamics.
b) Explain in detail about the Joule-Thomson effect.
II. Write notes on: (4×5=20 marks)
1. Explain the carnots cycle.
2. Define Adsorption isotherm. Explain freundlisch adsorption isotherm.
3. Write in detail about the Bomb calorimeter.
4. Explain the Assay of Oxygen.
III. Short Answers: (5×2=10 marks)
1. Define internal energy.
2. Enthalpy of a reaction.
3. Define catalyst.
4. Define ideal solutions and real solutions.
5. Define Adsorption.
AUGUST 2013
SECTION-A :
(Pharmaceutical Analysis)
I. Elaborate on: (1 x 20 =20)
1.a) What is buffer solution and explain about the buffer mixture of a weak acid and weak base and its salts.
b) Explain in detail about the Non aqueous titrations.
II. Write Notes on: (4 x 5 =20)
1. Write a note on diazotization titrations.
2. Explain complexometric titrations.
3.Write a note on Mohrs method and Fajan’s method.
4. Write a note on standardization of perchloric acid.
III. Short Answers: (5 x 2 =10)
1.Define precision.
2. Define iodimetry.
3. Define law of mass action.
4.Calibration of volumetric apparatus.
5.Choice of indicators.
SECTION-B :
(Physical Chemistry)
I. Elaborate on: (1 x 20 =20)
1. a)Define rate of reaction clarify with suitable examples and derive the equation for first order reaction.
b) Explain Hess’s law of constant heat of summation.
II. Write Notes on: (4 x 5 =20)
1.Define Colligative properties.
2.Joule-Thomson effect.
3.Define solutions with its types.
4.Write about the factors affecting the rate of chemical reaction.
III. Short Answers: (5 x 2 =10)
1. Trouton’s rule.
2.Define Phase rule.
3.Freundlisch adsorbtion isotherm.
4.Enthalpy of combustion.
5.Second law of thermodynamics.