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MSCCH09 Drugs and Pharmaceuticals M.Sc Question Bank : vmou.ac.in

Name of the University : Vardhman Mahaveer Open University
Degree : M.Sc
Department : Chemistry
Subject Code/Name : MSCCH-09 – Drugs and Pharmaceuticals
Year : II
Document Type : Question Bank
Website : vmou.ac.in

Download Model/Sample Question Paper : https://www.pdfquestion.in/uploads/vmou.ac.in/3708.-MSCCH-09_140.pdf

Drugs & Pharmaceuticals :

Section A :
1. Give the main use of Reserpine drug.

Related : VMOU MSCCH06 Reaction Mechanisms, Paricyclic Reactions, Organic Photochemistry, Stereochemistry M.Sc Question Bank : www.pdfquestion.in/3705.html

2. Define Random screening. (All types of compound in the bioassay –
3. Give the difference between Agonists and Antagonists.
4. What did you understand by receptors.
5. Draw the structure of captopril.
6. Define isosteres
7. Name the chemical entity used to replace another group –
8. Illustrate the structure of Diazepam
9. Write the name of drug, which is active against hyper tension.
10. Draw the structure of any sulphonamide drug of your choice
11. Give one use of Tentagel resin.
12. Define the tracelesslinker.
13. Define Combinational synthesis.
14. Define QSAR technique.
15. Limitation of the QSAR
16. Are the Prodrugs drug- Clarify it
17. Write uses of sulfisoxazole. (antibacterial drug)
18. Classify the bacteria (two gram +Ve and gram -Ve)
19. Difference between the gram positive and gram negative bacteria
20. Why methyl salicylic acid is a prodrug but sacilylic acid –
21. Clinical trial of drug for phase II studies.
22. Give two Ethical issue of clinical trial of drug
23. Figure out the major anatomic part of the CNS
24. Give the types of the Adrenergic stimulants
25. Example one neuro transmitter

26. What is main use of Propronalol Antagonist (anti hypertensive drug)
27. Define Enzyme inhibitors (its block the enzyme and prevent its normal catalytic action)
28. Give the use of salbutamol (treatment of asthma)
29. How many types of Antibodies found in our body.(IgG, IgA, IgM, IgD. IgE)
30. Write down the structure of Atropine
31. Give the advantage of Hansch Analysis (quick and easy conclusion, use of descriptors from small organic molecule may be applied to biological systems)
32. Give the use of Ldocaine. (dental anesthetical, common local anesthetic and anti anhythmic drug)
33. Describe the types of the histamine receptors (H1, H2, H3,H4)
34. Name the Sodium channel activators (Aconitine, Batrachotoxine)
35. Define the Sodium channel blockers (agents that block (intracellular /extracellular) the conduction of Na ions through Na channels)
36. DNA Topoisomerase inhibitors (enzyme important in DNA replication and transcription)
37. What are the antimicrobial agents. (drugs act against protozoa)
38. Draw the structure of Metronidazole.
39. How does DNA intercalating agents functions (planner molecule that can slipin DNA strands and causes the distortion of DNA structure)
40. State the classes of chiral drugs (NSAIDS, beta-blocker, ACB-inhibitors)
41. State the Pfeffers rule. (when a more active pure enantiomer is used higher the eudismic ratio, lower is the dose of drug required)
42. Define the eudismic ratio (= activity of eutomer / Activity of distomer)
43. Write the Structure of s-Ibuprofen
44. Define Catalyst. (enhance the rate of reaction without being consuming in reaction)
45. What did you understand by the Genetic engineering. (Genetic manipulation by induced mutation)
46. What did you understand by Fermentation, (It is a bio-catalytic microbial synthesis, involves the reproduction of microorganism in presence of a source of carbon and energy, readily available food stocks)
47. Main components of bioanalysis of a drug. (Absorption, distribution, metabolism, excretion)
48. Give the relationship between absorbance of the light by compound and concentration C when light travels length of L. (A=CL)
49. Which spectral technique is useful in structural identification of a drug (IR)
50. Which method do you prefer to separate the components of the drug mixture. (Mass Spectroscopy)

Section B :
1. Write a short note on the discovery of penicillin.
2. Differentiate the random screening with non random screening.
3. Discuss the types of Antagonism
4. Write the structures of captopril, cimetidine
5. Explain the importance of the X-ray crystallographic studies
6. Write short note on rigidification and simplification of the drug structures.
7. Illustrate the structure and uses of the suphonomide antibacterial drug.
8. Describe high through put screening (HTS).
9. How did the cluster analysis useful in drug development.
10. Discuss prodrugs and the principles involved in the design of prodrug.
11. Overview the QSAR and condition required for the applicability of QSAR.
12. Why azathioprine is used as immune suppresent drug instead
13. Discuss the historical development of anti metabolites.
14. Formulate the synthesis of sulphanilamide.
15. Write the structure of trimethiprin and mechanism of action.
16. Give the mechanism of the functioning of pencillin drug.
17. Describe the process of the functioning of salbactum.
18. Discuss the Hansch analysis of the transport of the drug
19. Describe the clinical trails under different phase studies.
20. Write a short note on importance and action
21. Brief the advantages of the Craig plots.
22. Describe the importance of the carbonic anhydrase and
23. Define the cholinergic angonist and illustrate their action as drug.
24. Elaborate the synthesis process of dopomine.
25. Write down the structure synthesis and uses of nicotinic

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