Name of the University : Kerala University of Health Sciences
Degree : B.Pharm
Subject Name : Organic Chemistry
Year : I
Document Type : Model Question Paper
Website : kuhs.ac.in
Download Model/Sample Question Paper :
September 2012 : https://www.pdfquestion.in/uploads/kuhs.ac.in/3500-1-Organic%20Chemistry.pdf
August 2011 : https://www.pdfquestion.in/uploads/kuhs.ac.in/3500-2-Organic%20Chemistry.pdf
March 2013 : https://www.pdfquestion.in/uploads/kuhs.ac.in/3500-3-Organic%20Chemistry.pdf
July 2011 : https://www.pdfquestion.in/uploads/kuhs.ac.in/3500-4-Organic%20Chemistry.pdf
April 2012 : https://www.pdfquestion.in/uploads/kuhs.ac.in/3500-5-Organic%20Chemistry.pdf
KUHS Organic Chemistry B.Pharm Question Paper
First Year B.Pharm Degree Examinations –
PHARMACEUTICAL CHEMISTRY – I :
Organic Chemistry :
Time: 3 Hours
Total Marks: 100
Related / Similar Question Papers :
KUHS B.Pharm 1st Year Question Papers
September 2012
Answer all Questions. :
Write equations wherever necessary. :
Essay : (3×10=30)
1. Describe resonance, hyper conjugation, mesomerism and inductive effect with examples.
2. Discuss the general methods of preparation and reactions of phenols.
3. Explain the mechanism of benzoin condensation and Reformatsky reaction.
Short notes : (14×5=70)
4. Mention the synthesis and importance of malonic ester .
5. Explain the mechanism of Cannizzaro reaction
6. Explain the mechanism of SN1 and SN2 reactions.
7. Explain Sachse-Mohr theory with example.
8. Explain the acidity of alkynes.
9. Discuss Kharasch effect and Bayer’s oxidation.
10.Explain Kekule’s structure of benzene.
11.Discuss the effect of substituents in electrophilic aromatic substitution reaction.
12.Explain with an example the mechanism of nucleophilic addition reaction of carbonyl compounds.
13.Mention any two important methods of preparation of carboxylic acids and alcohols.
14.Explain the basicity of amines.
15.Explain free radical substitution reaction of alkanes with mechanism.
16. Discuss Stability on conjugated dienes.
17.What are acid anhydrides . Mention any two methods of preparation of acid anhydrides.
August 2011
Time: 3 Hrs
Max. Marks: 100
Answer all questions :
Write equations wherever necessary :
Essay : (2×10 = 20)
1. Write a note on resonance, hyperconjugation, mesomeric effect and inductive effect with examples.
2. Explain the mechanism and synthetic application of Cannizaro’s reaction and Hofmann’s degradation.
Write short notes on: (10 x 5 = 50)
3. What is Kharasch effect. How does it give rise to anti-Markovnikov ‘s product.
4. Discuss three methods of preparation of alcohols and how do you distinguish between 1-propanol and 2-propanol.
5. Explain Walden’s inversion with example.
6. What is Williamson’s synthesis. Explain the action of hydro-iodic acid on ethers.
7. Classify amines with two examples for each and explain how they are separated in a mixture.
8. Explain the effect of substituents in electrophilic aromatic substitution.
9. Write two methods of synthesis and three chemical reactions of carboxylic acids.
10. Explain Kolbe-Schmidt reaction .
11.Write two examples of dehydrohalogenation and mention the mechanism of E2 elimination reaction.
12.Write two methods of synthesis of nitriles and explain their reactivity.
Answer briefly : (10 x 3 = 30)
13.Why aldehydes are more reactive than ketones in nucleophilic addition reaction.
14.Draw the picture of alkyl cation and explain its stabilization.
15. Explain Baeyer’s strain theory.
16. Arrange the following in the increasing order of acidic strength:HCOOH, CH3COOH, CH3CH2COOH, ChCOOH.
17. Explain keto-enol tautomerism in alkynes.
18. Explain Oppenauer oxidation .
19.What type of hybridisation is found in alkanes, alkenes and alkynes. Explain with one example for each.
20. Explain why chair form of cyclohexane is more stable than boat form.
21. Give the mechanism of hydrolysis of esters.
22. Explain why vinyl chloride is less reactive than ethyl chloride and allyl chloride is more reactive than vinyl chloride.
March 2013
Time: 3 Hours
Total Marks: 100
Answer all Questions. :
Write equations wherever necessary. :
Essay :
1. State Markonikoff’s rule and explain with suitable examples . (3×10=30)
2. Enumerate the concepts of Bayer’s strain theory and its limitations. Give reason for the stability of cyclohexanes
3. Explain the method of preparation and any three synthetic reactions of aceto acetic esters.
Short notes ; (14×5=70)
4. Explain polymerization reaction of alkenes with an example
5. Briefly explain hyper conjugation.
6. Explain the mechanism of electrophilic aromatic substitution reaction with an example
7. Cannizzaro’s reaction.
8. List any two methods of preparation of aldehydes and ketones.
9. Explain the relative reactivities of three classes of alcohols
10.List any two methods of preparation of ethers.
11.Define: bond angle , bond energy and Huckel’s rule.
12.ExplainWalden inversion with an example
13.Metal acetylide reaction.
14. . Explain the Hinsberg method of separation of amines.
15.Explain:
** Kolbe-Schmidt reaction
** Acylation reaction of amines.
16. Explain E2 elimination reaction with mechanism 17.Theory of reactivity in mono substituted benzenes.
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