Name of the University : Kerala University of Health Sciences
Degree : First Professional MBBS Degree
Subject Code/Name : Biochemistry
Paper : I & II
Document Type : Model Question Paper
Website : kuhs.ac.in
Download Model/Sample Question Paper :
PAPER I : https://www.pdfquestion.in/uploads/kuhs.ac.in/3391-BIOCHEMISTRY%20-%20PAPER%20II.pdf
PAPER II : https://www.pdfquestion.in/uploads/kuhs.ac.in/3391-BIOCHEMISTRY-%20PAPER%20I.pdf
KUHS Biochemistry-I Question Paper
Time: 3 Hours
Total Marks: 50
Related : Kerala University of Health Sciences Physiology-I MBBS Question Paper : www.pdfquestion.in/3389.html
Biochemistry Paper I
Answer all questions :
Draw diagrams wherever necessary :
Essay : (10)
1. Discuss the metabolism of phenylalanine.
Short essays : (2×5=10)
2. Digestion and absorption of lipids.
3. Describe glycogen metabolism.
Short notes : (5×3=15)
4. Mutarotation
5. Essential fatty acids.
6. Isoenzymes.
7. Co-enzyme Q
8. Fate of pyruvate.
Answer briefly : (5×2=10)
9. Regulation of cholesterol synthesis.
10. LDL receptor.
11. GABA
12. Albinism.
13. Ketogenic amino acids.
Give precise answers: (5×1=5)
14. What are epimers.
15. What is lecithin and mention its use.
16. Define iso-electric pH.
17. Name two transport proteins.
18. Mention two examples of biologically important peptides.
Biochemistry Paper II
Time : 3 hrs Max marks : 50
Answer all questions :
Draw diagrams wherever necessary :
Essay : (10)
1. Discuss in detail the mechanism by which kidney maintains the blood pH. What is meant by metabolic acidosis and how it is compensated. (1+6+3=10)
Short essays : (2×5=10)
2. Explain the degradation of haem
3. Discuss the process of transcription in prokaryotes
Short notes : (5×3=15)
4. Cytochrome p450
5. List the different functions of plasma proteins.
6. Describe the Wald’s visual cycle.
7. Antioxidants
8. Discuss the base repair mechanism of DNA
Answer briefly:(5×2=10)
9. Pellagra
10. Factors affecting iron absorption
11. DNA finger printing
12. Define gout and name three drugs used to treat gout.
13. Orotic aciduria
Give precise answers : (5×1=5)
14. Mention two features of mitochondrial DNA
15. List the functions of restriction endonucleases.
16. Define tumor markers and mention one example
17. The normal albumin-globulin ratio and mention a condition in which it is reversed
18. Mention the examples of partially acceptable missense mutation and unacceptable missense mutation
Syllabus
** Essays must be framed from topics with three stars.
** Five and three marks questions must be framed from topics with three stars or two stars.
[Theory : 160Hrs]
Paper 1 (90Hrs)
| S NO | TOPICS | Hrs |
| 1 | CELL | (2Hrs) |
| 1.1 | ** Structure and Functions of cell and cellular organelles | 1Hr |
| 1.2 | ** Diseases associated withorganelle. Fractionation of organelles (in brief) and their marker enzymes | 1Hr |
| 2 | BIOMOLECULES | (15Hr |
| 2.1 | PROTEINS:
** Classification of aminoacids based on structure, metabolic fate, nutritive value |
1Hr |
| 2.2 | ** Properties of amino acids: Ionic properties of amino acids, Isoelectric pH and its importance; Buffering action of aminoacids and proteins | 1Hr |
| 2.3 | ** Peptide bonds; Biologically important peptides;
** Structural organization of proteins Primary Structure of insulin |
1Hr |
| 2.4 | ** Secondary structure | 1 Hr |
| 2.5 | ** Tertiary and Quaternary structure ; Myoglobin, Collagen and hemoglobin; Protein folding in brief, Prion Diseases | 1Hr |
| 2.6 | * Proteins: Classification based on composition & solubility, shape, function and nutritional value, limiting aminoacids and mutual supplementation | 1Hr |
| 2.7 | ** Denaturation, Coagulation; Precipitation of protein –Isoelectric precipitation , precipitation using salts ,heavy metals and organic solvents | 1Hr |
|
2.8 |
CARBOHYDRATES : ** Classification,** Isomerism |
1Hr |
| 2.9 | ** Reactions: Reducing property ,Oxidation, Reduction, Dehydration and Condensation (Details of reactions along with practicals) | 1Hr |
| 2.10 | ** Glycosidic bonds – N linked & O linked with examples
** Amino sugars, deoxy sugars with examples ** Disaccharides – reducing & nonreducing , Highlight clinical importance of lactulose |
1Hr |
| 2.11 | ** Polysaccharides : Homopolysaccharides , Heteropolysaccharides
** Glycosaminoglycans – composition, distribution and function ** mucopolysaccharidosis – Types ,common features & enzyme deficiency |
1 Hr |
| 2.12 | *Blood group antigens – Basic composition &Types
**Dietary fibre – Definition, types function & clinical significance |
1Hr |
| 2.13 | LIPIDS : ** Definition, Classification with examples** Fatty acids: Definition, Alpha and omega numbering system, Classification ; Clinical significance of MUFA & PUFA; Essential fatty acids; Trans fatty acids |
1 Hr |
| 2.14 | ** Cholesterol : Structure, Biologically important compounds derived
* * TAG : Composition & Function ** Phospholipids – Composition & Functions ** Phospholipases- Clinical highlights: Viper venom ,Respiratory distress syndrome |
1 Hr |
| 2.15 | ** Membranes : Structure & Composition (Functions will be dealt in Physiology classes)
** Micelle & Liposomes |
1Hr |
| 3 | ENZYMES | (7Hrs) |
| 3.1 | ** Definition, IUBMB classification with examples, Coenzymes & Cofactors | 1Hr |
| 3.2 | ** Concept of active site, Specificity of enzymes ;Factors affecting enzyme activity , Km value and its significance | 1Hr |
| 3.3 | ** Enzyme inhibition : Competitive, noncompetitive, uncompetitive with examples | 1 Hr |