Organisation : University of Kerala
Degree : MSc.
Stream : Bioinformatics
Document Type : Model Question Paper
Website : https://www.keralauniversity.ac.in/downs
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University of Kerala MSc Bioinformatics Model Question Paper
** Download Model question paper for MSc Bioinformatics Course (2017 Admission) in the new evaluation pattern
Related : University of Kerala BO1221 General Informatics and Bioinformatics B.Sc Model Question Paper : www.pdfquestion.in/5449.html
BI 211 – Biomathematics & Statistics
Time: 3 Hrs.
Max. Marks: 75
Section A :
Answer any ten questions. Each carries two marks :
1. If U = {1,2,3,…9}, A= {1,2,3,4,5} and E={2,4,6,8}, Find (A\E)c
2. If U={1,2,3…9}, A={1,2,5,6}, B={2,5,7}, Verify De-Morgan’s laws.
3. Let R and S be the following relations on A={1,2,3} R= { (1,1),(1,2),(2,3),(3,1),(3,3)}
4. Define the logical operations conjunction and disjunction.
5. What are tautologies and contradiction?
6. Define predicate and give example for it.
7. Explain isomorphism of graphs.
8. What is an Euler graph?
9. What are the difference between bipartite graph and complete graphs?
10. Define correlation.
11. Give the formula for finding the arithmetic mean of a weighted data.
12. What are interpolation and extrapolation? (10 x2=20)
Section B :
Answer any five questions. Each carries seven marks :
13. Prove the following identities
(i) (AUB) ?(AUB C) =A
(ii) (AUB)\ (A?B)=(A\B) U (B\A)
14. Let R be the following equivalence relation on the Set A = { 1,2,3,4,5,6} R= {(1,1),(1,5),(2,2),(2,3),(2,6),(3,2),(3,3),(3,6),(4,4),(5,1),(5,5),(6,2) (6,3),(6,6)} Find the partition of A induced by R.
15. Construct the truth table for the proposition [ p?q) ^ (q? r)] + (p?r)
16. What are the types of quantifiers? Explain.
17. Let G be a connected planar graph with p vertices and q edged. Where p?3. Then prove that q ? 3p-6.
18. Calculate the mode in the following series.
Size 0-10 10-20 20-30 30-40 40-50 50-60 60-70
Frequency 5 7 19 18 16 10 5
19. To calculate the inverse of the following matrix
3 0 2
2 0 -2
0 1 1 (5 x 7=35)
Section C :
Answer any two questions. Each carries ten Marks
20. (i).Examine whether the following argument is valid or not. p?+q, r? q , r + +p
(ii).If 7 is less than 4, then 7 is not a prime number. 7 is not less than 4 7 is a prime number
21. (i). Prove that the sum of degrees of the vertices of a graph G is equal to twice the number of edges in G.
(ii). Prove that the sum of degrees of the regions of a map is equal to twice the number of edges.
22. Calculate the coefficient of correlation for the following data.
Series X: 2 3 4 5 6 7 8
Series Y: 4 5 6 12 9 5 4
BI 212 – Introduction To Bioinformatics & Databases
Time: 3 Hrs.
Max. Marks: 75
Section A :
Answer any ten questions. Each carries two marks
1. State the difference between global & local alignment.
2. Complete table of genetic information from the genome to phenotype of organism.
3. List any two protein databases.
4. Write the salient features of standard genetic code.
5. What do you understand by sensitivity and specificity in BLAST?
6. What is the difference between structural & functional genomics?
7. What are primary databases?
8. What is meant by structural database?
9. Write expansion
(a) EMBL
(b) DDBJ
10. What is e-value of alignment scores?
11. What is OMIM?
12. What is the purpose of data compression?
13. Name two tools used in phylogenetic analysis.
Section B :
Answer any five questions. Each carries seven marks :
13. What is meant by Affine Gap penalty?
14. Compare PAM & BLOSOM matrices.
15. Describe PHI-BLAST.
16. Discuss the importance of biological databases in bioinformatics. 17. Explain the working of BLAST based on your knowledge of sequence alignment.
18. Explain the concept of scoring matrices for aligning amino acid sequences. Briefly explain how PAM is derived?
19. What is meant by secondary database? What are the major secondary databases?
20. Illustrate Global alignment with suitable example. (5 x 7 =35)
Section C :
Answer any two questions. Each carries ten marks :
21. If you get a particular protein named ‘Keratin’. How will you retrieve its
(a) Nucleic acid sequence
(b) Protein sequence
(c) Carbohydrate binding site, if present.
(d) Protein chains
(e) Amino acid frequency etc? Describe briefly?
22. It is noted that major sequence alignments differ in approach computational complexity and accuracy. Do you agree with this? Explain with suitable examples.
23. Let S1= AATTCGCGTA & S2 = TATCGCTACA
(a) Build the complete dynamic programming table for these strings
(b) What is the edit distance between S1 & S2
(c) List all optimal global alignment between S1 & S2.
BI 213 – Biodiversity, Ecology & Evolution
Time: 3 Hrs.
Max. Marks: 75
Section A :
Answer any ten questions. Each carries two marks :
1. What is Red Data Book?
2. Differentiate Fundamental Niche and realized Niche?
3. Differentiate between insitu and ex-situ conservation?
4. Describe alpha, Beta and Gamma diversity?
5. Define Competitive exclusion principles?
6. Proteins are the macromolecules which evolved first. Justify the statement?
7. What is stereo chemical fitting?
8. What is ‘C- value paradox’?
9. What is molecular clock hypothesis?
10. Comment on Biological time scale and its importance in evolution?
11. What are Biosensors?
12. What is the importance of Wild life Protection Act 1972? (10 x 2=20)
Section B :
Answer any five questions. Each carries seven marks :
13. What are conserved sequences? How it is evolutionarily significant?
14. How ATP is evolved in the evolutionary time? Which is the source used at that time for the evolution of complex molecules?
15. Earth summit. A Global strategy. Comment on it?
16. How nature balances in intra specific and interspecific competition?
17. Describe the significance of Lotka & Voltera hypothesis in the population Dynamics?
18. What are protected areas? What is its importance in ecosystem conservation?
19. Describe about Hardy Weinberg equilibrium.
20. Briefly explain population growth curve. (5 x 7=35)
Section C :
Answer any two questions. Each carries ten marks :
21. What is the importance of biodiversity conservation in present and future? Explain briefly?
22. Describe energy flow? Geographical efficiency of ecosystem?
23. What is molecular evolution and explain the evolution of DNA & RNA, Amino acids, Codon, Protein? (2 x 10 =20)
BI 214 – Introduction To IT & C Programming
Time: 3 Hrs.
Max. Marks: 75
Section A :
Answer any ten questions. Each carries two marks :
1. Explain multi-tasking.
2. What are point and draw device?
3. What is machine language? Why is it required?
4. What is an interpreter? How does it differ from a compiler?
5. Explain posting.
6. Hardware is normally one time expense, whereas software is a continuing expense. Elaborate?
7. What is the purpose of ASCII?
8. How many times will the following program print “good”. Give reasons
9. What is the output of the following program?
#include<stdio.h>
main()
{
int a[10];
printf(“%d”, *a+10- *a+5);
10. What is the output of the following program?
#include<stdio.h>
main()
{
int x;
x=~!printf;
printf(“%d”, x);
}
12. Write the differences between entry controlled loops and exit controlled loops. (10 x2=20)
Section B :
Answer any five questions. Each carries seven marks
13. Write a program to read a number. If the number is odd multiply by 3 and add 1. If the number is even divide by 2. Continually apply the above operations to the intermediate results until the number reaches one.
14. Write a C functions to copy the contents of one file to other and to count the number of words in a file.
15. Name any four popular operating systems. Describe its main features.
16. Differentiate between the ways data are organized on a magnetic disk and an optical disk. Which data organization leads to faster random access time and why?
17. A programmer eliminates all language processor errors from his/her program, and then runs it to get printed results. The programmer therefore, concludes that the program is complete. Comment.
18. What are the limitations of an image scanner when it is used for inputting text documents? How does an OCR device overcome these limitations?
19. Briefly explain the control structures in C programming. (5 x 7=35)
Section C :
Answer any two questions. Each carries ten marks :
20. Name any four popular operating systems. Describe its main features.
21. A programmer eliminates all language processor errors from his/her program, and then runs it to get printed results. The programmer therefore, concludes that the program is complete. Comment.
22. Write a program to evaluate the following investment equation V=P (1+r)n. And print the tables which would give the value of V for various combination of the following values of P, R and N.
P: 1000, 2000, 3000, ……… 10,000
R: 0.10,0.11,0.12, ……… 0.20
N: 1,2,3,……10
P is the principal amount and V is the value of money at the end of n years. This equation can be recursively written as V=P(1+r) P=V
That is, the value of money at the end of first year becomes the principal amount for the next year and so on. (2 x 10 =20)